Dermatol Sinica – Page 6 – Pathogens Associated sulfanilamides with T cell receptors

Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospectsCancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects

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Most cancers stem cells (CSCs) with their self-renewal capability are accepted as cells which provoke tumors. CSCs are considered attention-grabbing targets for novel anticancer therapeutic brokers due to their affiliation

Impact of HLA type, age and chronic viral infection on peripheral T-cell receptor sharing between unrelated individualsImpact of HLA type, age and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals

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The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high diversity through somatic recombination of the

A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in MiceA Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice

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Retinoid X receptor (RXR) is a nuclear receptor that heterodimerizes with a number of nuclear receptors, integrating ligand-mediated alerts throughout the heterodimers. Artificial RXR agonists have been developed to treatment

Chimeric Antigen Receptor T-Cell Therapy: The Light of Day for OsteosarcomaChimeric Antigen Receptor T-Cell Therapy: The Light of Day for Osteosarcoma

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Osteosarcoma (OS) is the most typical malignant bone tumor, arising primarily in youngsters and adolescents. With the introduction of multiagent chemotherapy, the therapies of OS have remarkably improved, however the

Clonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein-Barr virus-associated nasopharyngeal carcinomaClonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein-Barr virus-associated nasopharyngeal carcinoma

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The nasopharyngeal epithelium is very prone to pathogenic an infection. Greater than 95% of nasopharyngeal carcinomas (NPCs) are Epstein-Barr virus (EBV)-associated epithelial cancers densely infiltrated with EBV-free lymphocytes. It stays

Chimeric antigen receptor-T cells immunotherapy for targeting breast cancerChimeric antigen receptor-T cells immunotherapy for targeting breast cancer

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Redirected chimeric antigen receptor (CAR) T-cells can acknowledge and eradicate most cancers cells in a serious histocompatibility advanced impartial method. Genetic engineering of T cells by means of CAR expression

Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptorsEnhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors

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For efficient focused remedy of most cancers with chemotherapy-loaded nanoparticles (NPs), antigens which might be selective for most cancers cells needs to be focused to minimise off-tumour toxicity. Human leukocyte

Predicting T Cell Receptor Antigen Specificity From Structural Features Derived From Homology Models of Receptor-Peptide-Major Histocompatibility ComplexesPredicting T Cell Receptor Antigen Specificity From Structural Features Derived From Homology Models of Receptor-Peptide-Major Histocompatibility Complexes

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The physical interaction between the T cell receptor (TCR) and its cognate antigen causes T cells to activate and participate in the immune response. Understanding this physical interaction is important

CXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cellsCXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cells

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The efficacy of chimeric antigen receptor (CAR) T continues to be not optimum for stable tumors, partly because of the lack of T cell infiltration to the tumor website. One

Interferon-gamma: an overview of signals, mechanisms and functions.Interferon-gamma: an overview of signals, mechanisms and functions.

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Interferon-gamma: an overview of signals, mechanisms and functions. Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding