Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivoCovalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo
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Sulfated glycosaminoglycans (sGAG) present interplay with organic mediator proteins. Though collagen-based biomaterials are broadly utilized in clinics, their mixture with high-sulfated hyaluronan is unexplored. This research goals to functionalize a