Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.
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The large protein titin performs structure-preserving capabilities within the sarcomere and is vital for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play essential roles in regulating