Interferon-gamma: an overview of signals, mechanisms and functions.

Interferon-gamma: an overview of signals, mechanisms and functions. post thumbnail image

Interferon-gamma: an overview of signals, mechanisms and functions.

Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN-gamma signal transduction is discussed, as well as signal regulation and factors conferring signal specificity.
Cellular effects of IFN-gamma are described, including up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogenassociated molecular patterns, such as tumor necrosis factor-alpha, interleukin-4, type I IFNs, and lipopolysaccharide are discussed.

A novel coronavirus associated with severe acute respiratory syndrome.

BACKGROUND
A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak.

dermatol-sinica

METHODS
We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens.
RESULTS
None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throat-swab specimen. Electron-microscopical examination revealed ultrastructural features characteristic of coronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies.
Consensus coronavirus primers designed to amplify a fragment of the polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population.
CONCLUSIONS
A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because of the death of Dr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.

Plant pathogens and integrated defence responses to infection.

Plants cannot move to escape environmental challenges. Biotic stresses result from a battery of potential pathogens: fungi, bacteria, nematodes and insects intercept the photosynthate produced by plants, and viruses use replication machinery at the host’s expense. Plants, in turn, have evolved sophisticated mechanisms to perceive such attacks, and to translate that perception into an adaptive response. Here, we review the current knowledge of recognition-dependent disease resistance in plants. We include a few crucial concepts to compare and contrast plant innate immunity with that more commonly associated with animals. There are appreciable differences, but also surprising parallels.

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.

The innate immune system recognizes pathogenassociated molecular patterns (PAMPs) that are expressed on infectious agents, but not on the host. Toll-like receptors (TLRs) recognize PAMPs and mediate the production of cytokines necessary for the development of effective immunity. Flagellin, a principal component of bacterial flagella, is a virulence factor that is recognized by the innate immune system in organisms as diverse as flies, plants and mammals. Here we report that mammalian TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and that activation of the receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production.
TLR5-stimulating activity was purified from Listeria monocytogenes culture supernatants and identified as flagellin by tandem mass spectrometry. Expression of L. monocytogenes flagellin in non-flagellated Escherichia coli conferred on the bacterium the ability to activate TLR5, whereas deletion of the flagellin genes from Salmonella typhimurium abrogated TLR5-stimulating activity. All known TLRs signal through the adaptor protein MyD88. Mice challenged with bacterial flagellin rapidly produced systemic interleukin-6, whereas MyD88-null mice did not respond to flagellin. Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens.

Circulating mitochondrial DAMPs cause inflammatory responses to injury.

Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogenassociated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can release endogenous ‘damage’-associated molecular patterns (DAMPs) that activate innate immunity. Mitochondria are evolutionary endosymbionts that were derived from bacteria and so might bear bacterial molecular motifs. Here we show that injury releases mitochondrial DAMPs (MTDs) into the circulation with functionally important immune consequences. MTDs include formyl peptides and mitochondrial DNA.
These activate human polymorphonuclear neutrophils (PMNs) through formyl peptide receptor-1 and Toll-like receptor (TLR) 9, respectively. MTDs promote PMN Ca(2+) flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo. Circulating MTDs can elicit neutrophil-mediated organ injury. Cellular disruption by trauma releases mitochondrial DAMPs with evolutionarily conserved similarities to bacterial PAMPs into the circulation. These signal through innate immune pathways identical to those activated in sepsis to create a sepsis-like state. The release of such mitochondrial ‘enemies within’ by cellular injury is a key link between trauma, inflammation and SIRS.

MOUSE ANTI HUMAN CD163: FITC

MBS225948-5x01mg 5x0.1mg
EUR 1785

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-48T 48T
EUR 346.8

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-48Tests 48 Tests Ask for price

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-96T 96T
EUR 559.2

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-96Tests 96 Tests
EUR 388

human CD163 antigen,CD163 LISA kit

201-12-0247 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-1096T 10*96T
EUR 4122

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-48wells 48 wells
EUR 300

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-596T 5*96T
EUR 2061

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-96wells 96 wells
EUR 458

Human CD163 antigen,CD163 ELISA KIT

JOT-EK0246Hu 96 wells Ask for price
Description: Human

Human CD163 antigen, CD163 ELISA Kit

MBS165165-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human CD163 antigen, CD163 ELISA Kit

MBS165165-48StripWells 48-Strip-Wells
EUR 285

Human CD163 antigen, CD163 ELISA Kit

MBS165165-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human CD163 antigen, CD163 ELISA Kit

MBS165165-96StripWells 96-Strip-Wells
EUR 425

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-48StripWells 48-Strip-Wells
EUR 550

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-96StripWells 96-Strip-Wells
EUR 765

human CD163 antigen,CD163 ELISA kit

YLA0098HU-48T 48T Ask for price

human CD163 antigen,CD163 ELISA kit

YLA0098HU-96T 96T Ask for price

Human CD163 Antigen, CD163 GENLISA ELISA

KBH0246 1 x 96 wells
EUR 286

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47162MH 25 µg
EUR 322.14
Description: Mouse

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47163MH 0.2 mg
EUR 659.4
Description: Mouse

Human CD163 antigen-CD163-ISA kit

QY-E05066 96T
EUR 400

Mouse Anti Human CD163, APC Conjugated mAb

MBS9431893-100Tests 100Tests
EUR 520

Mouse Anti Human CD163, APC Conjugated mAb

MBS9431893-25Tests 25Tests
EUR 275

Mouse Anti Human CD163, APC Conjugated mAb

MBS9431893-5x100Tests 5x100Tests
EUR 2195

CD163 (untagged)-Human CD163 molecule (CD163), transcript variant 2

SC308167 10 µg Ask for price

CD163 (untagged)-Human CD163 molecule (CD163), transcript variant 1

SC117495 10 µg Ask for price

PE anti-human CD163

E16FHP163-025 25 tests
EUR 433.33
Description: Available in various conjugation types.

PE anti-human CD163

E16FHP163-100 100 tests
EUR 953.33
Description: Available in various conjugation types.

Anti-Human CD163 PE

MBS696987-100Tests 100Tests
EUR 415

Anti-Human CD163 PE

MBS696987-25Tests 25Tests
EUR 225

Anti-Human CD163 PE

MBS696987-5x100Tests 5x100Tests
EUR 1820

Anti-Human CD163 Antibody

101-M291 100 µg
EUR 399
Description: CD163, also known as hemoglobin scavenger receptor, is a type I transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. Two alternatively spliced cytoplasmic variants of human CD163 exist. A soluble form of CD163 can also be released by metalloproteinase-mediated shedding of the extracellular domain. CD163 mediates the endocytosis of haptoglobin-hemoglobin complexes.

APC anti-human CD163

E16FHA163-025 25 tests
EUR 520
Description: Available in various conjugation types.

APC anti-human CD163

E16FHA163-100 100 tests
EUR 1191.67
Description: Available in various conjugation types.

Anti-Human CD163 APC

MBS696989-100Tests 100Tests
EUR 480

Anti-Human CD163 APC

MBS696989-25Tests 25Tests
EUR 245

Anti-Human CD163 APC

MBS696989-5x100Tests 5x100Tests
EUR 2115

APC anti-human CD163

MBS9459445-100Tests 100Tests
EUR 655

APC anti-human CD163

MBS9459445-25Tests 25Tests
EUR 355

APC anti-human CD163

MBS9459445-5x100Tests 5x100Tests
EUR 2790

FITC anti-human CD163

E16FHF163-025 25 tests
EUR 520
Description: Available in various conjugation types.

FITC anti-human CD163

E16FHF163-100 100 tests
EUR 1191.67
Description: Available in various conjugation types.

Biotin anti-human CD163

E16FHB163-025U 25 μg
EUR 346.67
Description: Available in various conjugation types.

Biotin anti-human CD163

E16FHB163-100U 100 μg
EUR 780
Description: Available in various conjugation types.

Purified anti-human CD163

E16FHU163-100U 100 μg
EUR 433.33
Description: Available in various conjugation types.

CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 1

RG208557 10 µg Ask for price

CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 2

RG212754 10 µg Ask for price

Rabbit Anti Human CD163 Monoclonal Clone ABCC-3

IRBAHUCD163ABCC3C100UL each
EUR 496
Description: Rabbit Anti Human CD163 Monoclonal Clone ABCC-3

Recombinant Human CD163/CD163 Protein, His Tag

E40KMH346 20ug
EUR 495

Human CD163 siRNA

20-abx910931
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 2

RC212754 10 µg Ask for price

CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 1

RC208557 10 µg Ask for price

Human CD163 Protein

E40KMPH6242 20ug
EUR 495

Recombinant Human CD163

MBS147285-0001mg 0.001mg
EUR 240

Recombinant Human CD163

MBS147285-0005mg 0.005mg
EUR 310

Recombinant Human CD163

MBS147285-005mg 0.05mg
EUR 1360

Recombinant Human CD163

MBS147285-5x005mg 5x0.05mg
EUR 5800

CD163 siRNA (Human)

MBS8229683-15nmol 15nmol
EUR 405

CD163 siRNA (Human)

MBS8229683-30nmol 30nmol
EUR 565

CD163 siRNA (Human)

MBS8229683-5x30nmol 5x30nmol
EUR 2450

Anti-Human CD163 Antibody (M130)

MBS1564482-01mg 0.1mg
EUR 340

Anti-Human CD163 Antibody (M130)

MBS1564482-5x01mg 5x0.1mg
EUR 1235

Anti-Human CD163 Antibody (AB101)

MBS1570008-01mg 0.1mg
EUR 405

Anti-Human CD163 Antibody (AB101)

MBS1570008-5x01mg 5x0.1mg
EUR 1520

PE-Cy7 anti-human CD163

E16FHN163-025 25 tests
EUR 650
Description: Available in various conjugation types.

PE-Cy7 anti-human CD163

E16FHN163-100 100 tests
EUR 1408.33
Description: Available in various conjugation types.

APC-Cy7 anti-human CD163

E16FHO163-025 25 tests
EUR 650
Description: Available in various conjugation types.

APC-Cy7 anti-human CD163

E16FHO163-100 100 tests
EUR 1408.33
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163

E16FHS163-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163

E16FHS163-100 100 tests
EUR 1278.33
Description: Available in various conjugation types.

Anti-Human CD163 PE-Cyanine7

MBS696988-100Tests 100Tests
EUR 505

Anti-Human CD163 PE-Cyanine7

MBS696988-25Tests 25Tests
EUR 270

Anti-Human CD163 PE-Cyanine7

MBS696988-5x100Tests 5x100Tests
EUR 2220

Mouse Monoclonal anti-human CD163

hAP-0161 100ug
EUR 250

Mouse Monoclonal anti-human CD163

hAP-0161A 50ug
EUR 400

Human CD163, Fc Tag

E24PHA282 50 μg
EUR 250

Human, Rat, Mouse CD163 antibody

P0405 100ul
EUR 150

Human CD163, His Tag

E24PHA281 50 μg
EUR 250

Human CD163 ELISA Kit

ELA-E1726h 96 Tests
EUR 988.8

Human CD163 ELISA Kit

EK5296 96 tests
EUR 599

Human CD163 ELISA Kit

GWB-SKR207 96 Tests Ask for price

Human CD163 ELISA Kit

LF-EK50890 1×96T
EUR 777.6

Human CD163 ELISA Kit

MBS3800092-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human CD163 ELISA Kit

MBS3800092-48StripWells 48-Strip-Wells
EUR 550

Human CD163 ELISA Kit

MBS3800092-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human CD163 ELISA Kit

MBS3800092-96StripWells 96-Strip-Wells
EUR 765

Human CD163 ELISA Kit

MBS824474-5x96Tests 5x96Tests
EUR 2880

Human CD163 ELISA Kit

MBS824474-96Tests 96Tests
EUR 645

Human CD163 shRNA Plasmid

20-abx956176
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human CD163 Protein Lysate

MBS138999-002mg 0.02mg
EUR 365

Human CD163 Protein Lysate

MBS138999-5x002mg 5x0.02mg
EUR 1410

Human CD163 Recombinant Protein

PROTQ86VB7 10ug
EUR 350
Description: Human CD163 Recombinant Protein expressed in Baculovirus with His-tag. Sequence domain: 42-1050aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

Recombinant Human CD163 Protein

RP02295 500μg
EUR 244.43

CD163 (Human) ELISA Kit

EKA52023-5x96T 5x96T Ask for price

CD163 (Human) ELISA Kit

EKA52023-96T 96T
EUR 446.9

Human CellExp? CD163, Human recombinant

9226-10 each
EUR 366

Human CellExp? CD163, Human recombinant

9226-50 each
EUR 927.6

anti- CD163/M130 Antibody

FNab09771 100µg
EUR 658.5
Description: Antibody raised against CD163/M130 

Mouse Monoclonal anti-Human CD163 Antibody

xAP-0134 100ug
EUR 280

Mouse Monoclonal anti-Human CD163 Antibody

xAP-0135 100ug
EUR 280

CD163 Rabbit anti-Human Polyclonal Antibody

MBS2402782-005mL 0.05mL
EUR 615

CD163 Rabbit anti-Human Polyclonal Antibody

MBS2402782-5x005mL 5x0.05mL
EUR 2605

CD163 Rabbit anti-Human Polyclonal Antibody

MBS2403148-005mg 0.05mg
EUR 615

CD163 Rabbit anti-Human Polyclonal Antibody

MBS2403148-5x005mg 5x0.05mg
EUR 2605

Anti-Hu CD163 PE

1P-645-T025 25 tests
EUR 121

Anti-Hu CD163 PE

1P-645-T100 100 tests
EUR 242

Anti-Hu CD163 PE

MBS1800644-100Tests 100Tests
EUR 345

Anti-Hu CD163 PE

MBS1800644-5x100Tests 5x100Tests
EUR 1300

Anti-Hu CD163 APC

1A-645-T025 25 tests
EUR 121

Anti-Hu CD163 APC

1A-645-T100 100 tests
EUR 242

Anti-Hu CD163 APC

MBS1800643-100Tests 100Tests
EUR 345

Anti-Hu CD163 APC

MBS1800643-5x100Tests 5x100Tests
EUR 1300

MOUSE ANTI PIG CD163

MBS224621-01mg 0.1mg
EUR 420

MOUSE ANTI PIG CD163

MBS224621-5x01mg 5x0.1mg
EUR 1715

MOUSE ANTI RAT CD163

MBS216354-01mg 0.1mg
EUR 455

MOUSE ANTI RAT CD163

MBS216354-5x01mg 5x0.1mg
EUR 1885

MOUSE ANTI RAT CD163

MBS216356-025mg 0.25mg
EUR 620

MOUSE ANTI RAT CD163

MBS216356-5x025mg 5x0.25mg
EUR 2620

Anti-Hu CD163 Purified

11-645-C025 0.025 mg
EUR 71.5

Anti-Hu CD163 Purified

11-645-C100 0.1 mg
EUR 143

Anti-Hu CD163 Purified

MBS1800642-01mg 0.1mg
EUR 260

Anti-Hu CD163 Purified

MBS1800642-5x01mg 5x0.1mg
EUR 930

Human CD163 Protein, His Tag

CD3-H52E8 1mg
EUR 381.5
Description: Human CD163, His Tag (CD3-H52E8) is expressed from human 293 cells (HEK293). It contains AA Ser 42 - Ser 1045 (Accession # Q86VB7).

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)

MBS9511396-12mLRTU 12mL(RTU)
EUR 530

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)

MBS9511396-3mLRTU 3mL(RTU)
EUR 240

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)

MBS9511396-5x12mLRTU 5x12mL(RTU)
EUR 2230

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)

MBS9511396-6mLRTU 6mL(RTU)
EUR 325

CD163 Antigen (CD163) Rabbit anti-Human Polyclonal (N-Terminus) (K20-T) Antibody

GWB-B1E200 0.05 ml Ask for price

Human CD163 knockout cell line

ABC-KH2671 1 vial Ask for price
Description: Human CD163 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CD163 PicoKine ELISA Kit

MBS176496-5x96StripWells 5x96-Strip-Wells
EUR 2755

Human CD163 PicoKine ELISA Kit

MBS176496-96StripWells 96-Strip-Wells
EUR 600

Human CD163 knockdown cell line

ABC-KD2671 1 vial Ask for price
Description: Human CD163 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human CD163 Protein Lysate 20ug

IHUCD163PLLY20UG each
EUR 213
Description: Human CD163 Protein Lysate 20ug

Rabbit Polyclonal to Human CD163

MBS245302-0125mL 0.125mL
EUR 620

Rabbit Polyclonal to Human CD163

MBS245302-5x0125mL 5x0.125mL
EUR 2695

CD163 (NM_004244) Human Recombinant Protein

E45H38041M5 20 ug
EUR 785.42

CD163, Human, mAb RM3/1

MBS584200-01mg 0.1mg
EUR 710

CD163, Human, mAb RM3/1

MBS584200-05mg 0.5mg
EUR 1695

CD163, Human, mAb RM3/1

MBS584200-1mg 1mg
EUR 2370

CD163, Human, mAb RM3/1

MBS584200-5mg 5mg
EUR 7845

Recombinant Human CD163, GST-tagged

CD163-10910H 25ug
EUR 255.2
Description: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.

CD163 ORF Vector (Human) (pORF)

ORF017045 1.0 ug DNA
EUR 486

CD163 (Human) LumiAb ELISA Kit

MBS9510961-1x96Wells 1x96Wells
EUR 520

CD163 (Human) LumiAb ELISA Kit

MBS9510961-5x96Wells 5x96Wells
EUR 2395

PE Anti-human CD163 Antibody *GHI/61*

116301K0 25 tests
EUR 391
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*

116301K0-25tests 25 tests
EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*

116301K1 100 tests
EUR 1015
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*

116301K1-100tests 100 tests
EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*

116301K2 500 tests
EUR 3044
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*

116301K2-500tests 500 tests
EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

CD163 (Human) OmniKine ELISA Kit

MBS9502033-1x96Wells 1x96Wells
EUR 500

CD163 (Human) OmniKine ELISA Kit

MBS9502033-5x96Wells 5x96Wells
EUR 2300

CD163 (Human) Sandwich ELISA Kit

OK-0312 1Kit
EUR 280
Description: CD163 (Human) Colorimetric Sandwich ELISA Kit

APC Anti-human CD163 Antibody *GHI/61*

116301B0 25 tests
EUR 391
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*

116301B0-25tests 25 tests
EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*

116301B1 100 tests
EUR 1015
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*

116301B1-100tests 100 tests
EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*

116301B2 500 tests
EUR 3044
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*

116301B2-500tests 500 tests
EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Alexa Fluor® 647 anti-human CD163

E16FHK163-025 25 tests
EUR 433.33
Description: Available in various conjugation types.

Alexa Fluor® 647 anti-human CD163

E16FHK163-100 100 tests
EUR 975
Description: Available in various conjugation types.

CD163 ELISA Kit (Human) (OKCD07621)

OKCD07621 96 Wells
EUR 1123.2
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.273ng/mL

CD163 ELISA Kit (Human) (OKBB00786)

OKBB00786 96 Wells
EUR 606
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml

CD163 ELISA Kit (Human) (OKBB01513)

OKBB01513 96 Wells
EUR 684
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml

CD163 ELISA Kit (Human) (OKAN04666)

OKAN04666 96 Wells
EUR 950.4
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.273 ng/mL

FITC Anti-human CD163 Antibody *GHI/61*

116301G0 100 tests
EUR 558
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

FITC Anti-human CD163 Antibody *GHI/61*

116301G0-100tests 100 tests
EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

FITC Anti-human CD163 Antibody *GHI/61*

116301G1 500 tests
EUR 2093
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

FITC Anti-human CD163 Antibody *GHI/61*

116301G1-500tests 500 tests
EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*

116301H0 100 tests
EUR 558
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*

116301H0-100tests 100 tests
EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*

116301H1 500 tests
EUR 2093
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*

116301H1-500tests 500 tests
EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*

116301S0 25 tests
EUR 391
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*

116301S0-25tests 25 tests
EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*

116301S1 100 tests
EUR 1015
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*

116301S1-100tests 100 tests
EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*

116301S2 500 tests
EUR 3044
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*

116301S2-500tests 500 tests
EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

QuickDetect? CD163 (Human) ELISA Kit

K4422-100 each
EUR 966

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I0 100 tests
EUR 558
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I0-100tests 100 tests
EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I1 500 tests
EUR 2093
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I1-500tests 500 tests
EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

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