Most cancers is among the many main causes of demise worldwide. Due to this fact, bettering most cancers therapeutic methods utilizing novel options is a high precedence on the up to date scientific agenda. An instance of such methods is immunotherapy, which is predicated on educating the immune system to acknowledge, assault, and kill malignant most cancers cells. A number of kinds of immunotherapies are at present used to deal with most cancers, together with adoptive cell remedy (ACT).
Chimeric Antigen Receptors remedy (CAR remedy) is a type of ATC the place autologous T cells are genetically engineered to specific CARs (CAR-T cells) to particularly kill the tumor cells. CAR-T cell remedy is a chance to deal with sufferers that haven’t responded to different first-line most cancers therapies.
These days, this sort of remedy nonetheless has many challenges to beat to be thought of as a first-line scientific therapy. This rising expertise remains to be categorised as a complicated remedy from the pharmaceutical viewpoint, therefore, for it to be utilized it should firstly meet sure necessities demanded by the authority.
Because of this, the purpose of this overview is to current a world imaginative and prescient of various immunotherapies and give attention to CAR-T cell expertise analyzing its parts, its historical past, and its challenges. Moreover, analyzing the chance areas for CAR-T expertise to grow to be an inexpensive therapy modality taking the fundamental, scientific, and sensible elements into consideration.

Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph evaluation (CoNGA)
Hyperlinks between T cell clonotypes, as outlined by T cell receptor (TCR) sequences, and phenotype, as mirrored in gene expression (GEX) profiles, floor protein expression and peptide:main histocompatibility complicated binding, can reveal purposeful relationships past the options shared by clonally associated cells. Right here we current clonotype neighbor graph evaluation (CoNGA), a graph theoretic method that identifies correlations between GEX profile and TCR sequence via statistical evaluation of GEX and TCR similarity graphs.
Utilizing CoNGA, we uncovered associations between TCR sequence and GEX profiles that embody a beforehand undescribed ‘pure lymphocyte’ inhabitants of human circulating CD8+ T cells and a set of TCR sequence determinants of differentiation in thymocytes. These examples present that CoNGA may assist elucidate complicated relationships between TCR sequence and T cell phenotype in massive, heterogeneous, single-cell datasets.
Chimeric antigen receptor (CAR) T-cell remedy has exhibited promising scientific outcomes in treating relapsed/refractory (R/R) B-cell hematologic malignancies. Present research have proven an in depth correlation between baseline tumor burden and therapeutic response in CAR-T cell remedy.
Nevertheless, the roles of PET/CT metabolic parameters, resembling metabolic tumor quantity (MTV) and complete lesion glycolysis (TLG), stay unclear on this setting. On this examine, we retrospectively reviewed 41 R/R NHL sufferers. 18F-FDG PET/CT was used to measure the typical standardized uptake worth (SUVavg), MTV, and TLG of the lymphomatous lesions.
SARS-CoV-2-reactive T cell receptors remoted from convalescent COVID-19 sufferers confer potent T cell effector perform
Each B cells and T cells are concerned in an efficient immune response to SARS-CoV-2, the disease-causing virus of COVID-19. Whereas B cells – with the indispensable assist of CD4+ T cells – are important to generate neutralizing antibodies, T cells on their very own have been acknowledged as one other main participant in efficient anti-SARS-CoV-2 immunity. On this report, we offer insights into the traits of particular person HLA-A*02:01- and HLA-A*24:02-restricted SARS-CoV-2-reactive TCRs, remoted from convalescent COVID-19 sufferers.
We noticed that SARS-CoV-2-reactive T cell populations have been clearly detectable in convalescent samples and that TCRs remoted from these T cell clones have been extremely purposeful upon ectopic re-expression. The SARS-CoV-2-reactive TCRs described on this report mediated potent TCR signalling in reporter assays with low nanomolar EC50 values.
We additional exhibit that these SARS-CoV-2-reactive TCRs conferred highly effective T cell effector perform to main CD8+ T cells as evident by a sturdy anti-SARS-CoV-2 IFN-γ response and in vitro cytotoxicity. We additionally present an instance of long-lasting anti-SARS-CoV-2 reminiscence response by re-isolation of one of many retrieved TCRs 5 months after preliminary sampling.
Taken collectively, these findings contribute to a greater understanding of anti-SARS-CoV-2 T cell immunity and should contribute to paving the way in which in direction of immunotherapeutics approaches concentrating on SARS-CoV-2. This text is protected by copyright. All rights reserved.
Phosphorylation of CrkL S114 induced by frequent gamma chain cytokines and T–cell receptor sign transduction
T-cell activation and mobile growth by frequent gamma chain cytokines resembling Interleukin-2 is critical for adaptive immunity. Nevertheless, when unregulated these similar pathways promote pathologies starting from autoimmune problems to most cancers. Whereas the purposeful position of Interleukin-2 and downstream effector molecules is comparatively clear, the repertoire of phosphoregulatory proteins downstream of this pathway is incomplete.
To establish phosphoproteins downstream of frequent gamma chain receptor, YT cells have been radiolabeled with [32P]-orthophosphate and stimulated with Interleukin-2. Subsequently, tyrosine phosphorylated proteins have been immunopurified and subjected to tandem mass spectrometry-leading to the identification of CrkL.
Phosphoamino acid evaluation revealed concurrent serine phosphorylation of CrkL and was later recognized as S114 by mass spectrometry evaluation. S114 was inducible via stimulation with Interleukin-2 or T-cell receptor stimulation. Polyclonal antibodies have been generated towards CrkL phospho-S114, and used to point out its inducibility by a number of stimuli. These findings verify CrkL as an Interleukin-2 responsive protein that turns into phosphorylated at S114 by a kinase/s downstream of PI3K and MEK/ERK signaling.
A number of mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR
Our outcomes point out that TRAF3 negatively regulates GITR capabilities in a number of methods. First, expression of GITR protein was elevated in TRAF3-deficient T cells, ensuing from each transcriptional and post-translational regulation that led to higher GITR transcript ranges, in addition to enhanced GITR protein stability.
anti- Betacellulin antibody |
FNab00883 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Betacellulin |
Human Betacellulin CLIA Kit |
MBS8425178-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Recombinant Human Betacellulin |
7-00223 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Betacellulin |
7-00224 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human Betacellulin |
7-00225 |
CHI Scientific |
1mg |
Ask for price |
Human Betacellulin (Recombinant) |
22060316-1 |
Bio-WORLD |
5 µg |
EUR 190.94 |
Recombinant Human Betacellulin |
cyt-330-1mg |
ProSpec Tany |
1mg |
EUR 2700 |
Recombinant Human Betacellulin |
cyt-330-20g |
ProSpec Tany |
20µg |
EUR 145 |
Recombinant Human Betacellulin |
cyt-330-5g |
ProSpec Tany |
5µg |
EUR 60 |
Recombinant Human Betacellulin |
AP60110 |
SAB |
100ug |
EUR 896 |
|
Recombinant Human Betacellulin |
MBS142207-0005mg |
MyBiosource |
0.005mg |
EUR 240 |
Recombinant Human Betacellulin |
MBS142207-002mg |
MyBiosource |
0.02mg |
EUR 310 |
Recombinant Human Betacellulin |
MBS142207-1mg |
MyBiosource |
1mg |
EUR 2880 |
Recombinant Human Betacellulin |
MBS142207-5x1mg |
MyBiosource |
5x1mg |
EUR 12630 |
Recombinant Human BetaCellulin |
HEOPP-0212 |
Cyagen |
5ug |
Ask for price |
Recombinant Human Betacellulin |
P1308-.005 |
ApexBio |
5ug |
EUR 108.8 |
Description: Peptides & Proteins|Recombinant Proteins |
Recombinant Human Betacellulin |
P1308-.1 |
ApexBio |
100ug |
EUR 900 |
Description: Peptides & Proteins|Recombinant Proteins |
Recombinant Human Betacellulin |
P1308-.5 |
ApexBio |
500ug |
EUR 2021.6 |
Description: Peptides & Proteins|Recombinant Proteins |
Human Betacellulin ELISA Kit |
IHUBTCKT |
Innovative research |
each |
EUR 702 |
|
Description: Human Betacellulin ELISA Kit |
Human Betacellulin ELISA Kit |
MBS138113-1Kit |
MyBiosource |
1Kit |
EUR 755 |
Human Betacellulin ELISA Kit |
MBS138113-5x1Kit |
MyBiosource |
5x1Kit |
EUR 3455 |
Human Betacellulin ELISA KIT |
E42EH-268 |
EnoGene |
96T/48T |
EUR 795 |
Human Betacellulin ELISA Kit |
GWB-SKR006 |
GenWay Biotech |
96 Tests |
Ask for price |
Human Betacellulin ELISA Kit |
MBS009811-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Human Betacellulin ELISA Kit |
MBS009811-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Human Betacellulin ELISA Kit |
MBS009811-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Human Betacellulin ELISA Kit |
MBS009811-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
Human betacellulin ELISA Kit |
MBS727932-48StripWellsCompetitive |
MyBiosource |
48-Strip-Wells-(Competitive) |
EUR 485 |
Human betacellulin ELISA Kit |
MBS727932-48StripWellsSandwich |
MyBiosource |
48-Strip-Wells-(Sandwich) |
EUR 485 |
Human betacellulin ELISA Kit |
MBS727932-5x96StripWellsCompetitive |
MyBiosource |
5x96-Strip-Wells-(Competitive) |
EUR 3020 |
Human betacellulin ELISA Kit |
MBS727932-96StripWellsCompetitive |
MyBiosource |
96-Strip-Wells-(Competitive) |
EUR 690 |
Human betacellulin ELISA Kit |
MBS727932-96StripWellsSandwich |
MyBiosource |
96-Strip-Wells-(Sandwich) |
EUR 690 |
Human Betacellulin ELISA Kit |
MBS763506-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 3900 |
Human Betacellulin ELISA Kit |
MBS763506-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 340 |
Human Betacellulin ELISA Kit |
MBS763506-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2045 |
Human Betacellulin ELISA Kit |
MBS763506-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 455 |
Human Betacellulin ELISA Kit |
MBS824733-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2880 |
Human Betacellulin ELISA Kit |
MBS824733-96Tests |
MyBiosource |
96Tests |
EUR 645 |
Betacellulin, Recombinant, Human |
MBS650210-0005mg |
MyBiosource |
0.005mg |
EUR 340 |
Betacellulin, Recombinant, Human |
MBS650210-002mg |
MyBiosource |
0.02mg |
EUR 490 |
Betacellulin, Recombinant, Human |
MBS650210-5x002mg |
MyBiosource |
5x0.02mg |
EUR 2055 |
Betacellulin Human Recombinant |
rAP-0363 |
Angio Proteomie |
Inquiry |
Ask for price |
Human Betacellulin (bTC) Protein |
abx065524-100g |
Abbexa |
100 µg |
EUR 537.5 |
Human Betacellulin (bTC) Protein |
20-abx065524 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
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|
- 10 ug
- 50 ug
- 100 ug
- 200 ug
- 1 mg
|
|
Human Betacellulin (bTC) Protein |
abx065524-10g |
Abbexa |
10 µg |
EUR 212.5 |
Human Betacellulin (bTC) Protein |
abx065524-50g |
Abbexa |
50 µg |
EUR 375 |
Human Betacellulin GENLISA ELISA |
KB1015 |
Krishgen |
1 x 96 wells |
EUR 198 |
Human Betacellulin (bTC) CLIA Kit |
abx196482-100l |
Abbexa |
100 µl |
Ask for price |
Human Betacellulin (bTC) CLIA Kit |
abx196482-50l |
Abbexa |
50 µl |
EUR 618.75 |
Human Betacellulin (bTC) CLIA Kit |
abx196482-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Betacellulin (BTC) CLIA Kit |
20-abx491043 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 96 tests
- 5 × 96 tests
- 10 × 96 tests
|
|
Human Betacellulin, BTC ELISA Kit |
DEIA089 |
Creative Diagnostics |
10 plates |
EUR 2051.28 |
Description: serum, plasma, other biological fluids |
Human Betacellulin (bTC) ELISA Kit |
DLR-bTC-Hu |
DL Develop |
96T |
EUR 422 |
|
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Human Betacellulin (bTC) ELISA Kit |
DLR-bTC-Hu-48T |
DL Develop |
48T |
EUR 574.8 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Human Betacellulin (bTC) ELISA Kit |
DLR-bTC-Hu-96T |
DL Develop |
96T |
EUR 745.2 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Human Betacellulin (BTC) ELISA Kit |
abx250182-96tests |
Abbexa |
96 tests |
EUR 493.75 |
|
Human Betacellulin (BTC) ELISA Kit |
abx570040-96tests |
Abbexa |
96 tests |
EUR 801.6 |
|
Human Betacellulin (bTC) ELISA Kit |
DL-bTC-Hu |
DL Develop |
96T |
EUR 402 |
|
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Human Betacellulin/BTC ELISA Kit |
EK5454 |
SAB |
96 tests |
EUR 599 |
|
Human Betacellulin(BTC) ELISA Kit |
EIA07641h |
Enlibio |
each |
EUR 430 |
Human Betacellulin (bTC) ELISA Kit |
EK12923 |
SAB |
96Т |
EUR 768 |
|
Human Betacellulin/BTC ELISA kit |
E22-HC017.48 |
EnoGene |
48T |
EUR 295 |
|
Description: 15pg/ml |
Human Betacellulin/BTC ELISA kit |
E22-HC017.96 |
EnoGene |
96T |
EUR 395 |
|
Description: 15pg/ml |
Human Betacellulin/BTC ELISA Kit |
LF-EK50996 |
Abfrontier |
1×96T |
EUR 777.6 |
Human Betacellulin (bTC) ELISA Kit |
MBS452002-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 4700 |
Human Betacellulin (bTC) ELISA Kit |
MBS452002-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 410 |
Human Betacellulin (bTC) ELISA Kit |
MBS452002-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2410 |
Human Betacellulin (bTC) ELISA Kit |
MBS452002-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 545 |
Human Betacellulin (bTC) ELISA Kit |
MBS457991-10x96Tests |
MyBiosource |
10x96Tests |
EUR 4890 |
Human Betacellulin (bTC) ELISA Kit |
MBS457991-48Tests |
MyBiosource |
48Tests |
EUR 425 |
Human Betacellulin (bTC) ELISA Kit |
MBS457991-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2495 |
Human Betacellulin (bTC) ELISA Kit |
MBS457991-96Tests |
MyBiosource |
96Tests |
EUR 560 |
Human Betacellulin (bTC) ELISA Kit |
MBS2020247-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 4910 |
Human Betacellulin (bTC) ELISA Kit |
MBS2020247-24StripWells |
MyBiosource |
24-Strip-Wells |
EUR 340 |
Human Betacellulin (bTC) ELISA Kit |
MBS2020247-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 500 |
Human Betacellulin (bTC) ELISA Kit |
MBS2020247-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2675 |
Human Betacellulin (bTC) ELISA Kit |
MBS2020247-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 665 |
Human Betacellulin (BTC) ELISA Kit |
MBS2610656-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 3040 |
Human Betacellulin (BTC) ELISA Kit |
MBS2610656-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 285 |
Human Betacellulin (BTC) ELISA Kit |
MBS2610656-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 1670 |
Human Betacellulin (BTC) ELISA Kit |
MBS2610656-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 405 |
Human Betacellulin (bTC) ELISA Kit |
MBS2701248-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 2830 |
Human Betacellulin (bTC) ELISA Kit |
MBS2701248-24StripWells |
MyBiosource |
24-Strip-Wells |
EUR 240 |
Human Betacellulin (bTC) ELISA Kit |
MBS2701248-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 315 |
Human Betacellulin (bTC) ELISA Kit |
MBS2701248-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 1480 |
Human Betacellulin (bTC) ELISA Kit |
MBS2701248-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 385 |
Human Betacellulin/BTC ELISA Kit |
MBS8579158-48Tests |
MyBiosource |
48Tests |
EUR 390 |
Human Betacellulin/BTC ELISA Kit |
MBS8579158-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2275 |
Human Betacellulin/BTC ELISA Kit |
MBS8579158-96Tests |
MyBiosource |
96Tests |
EUR 495 |
Human Betacellulin (bTC) ELISA Kit |
SEA112Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5128.02 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Human Betacellulin (bTC) ELISA Kit |
SEA112Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 527.48 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Human Betacellulin (bTC) ELISA Kit |
SEA112Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 702.12 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Human Betacellulin (bTC) ELISA Kit |
SEA112Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2799.54 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Human Betacellulin (bTC) ELISA Kit |
4-SEA112Hu |
Cloud-Clone |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 1 plate of 96 wells
- 5 plates of 96 wells
- 10 plates of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species. |
Human Betacellulin (bTC) ELISA Kit |
RD-bTC-Hu-48T |
Reddot Biotech |
48T |
EUR 432 |
|
Description: sandwich |
Human Betacellulin (bTC) ELISA Kit |
RD-bTC-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 573.6 |
Human Betacellulin (bTC) ELISA Kit |
RD-bTC-Hu-96T |
Reddot Biotech |
96T |
EUR 617 |
|
Description: sandwich |
Human Betacellulin (bTC) ELISA Kit |
RD-bTC-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 794.4 |
Human Betacellulin (bTC) ELISA Kit |
RDR-bTC-Hu-48T |
Reddot Biotech |
48T |
EUR 454 |
|
Description: sandwich |
Human Betacellulin (bTC) ELISA Kit |
RDR-bTC-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 600 |
Human Betacellulin (bTC) ELISA Kit |
RDR-bTC-Hu-96T |
Reddot Biotech |
96T |
EUR 648 |
|
Description: sandwich |
Human Betacellulin (bTC) ELISA Kit |
RDR-bTC-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 830.4 |
Recombinant Human Betacellulin, HEK |
cyt-1188-10g |
ProSpec Tany |
10µg |
EUR 145 |
Recombinant Human Betacellulin, HEK |
cyt-1188-1mg |
ProSpec Tany |
1mg |
EUR 5200 |
Recombinant Human Betacellulin, HEK |
cyt-1188-2g |
ProSpec Tany |
2µg |
EUR 60 |
Recombinant Human Betacellulin, HEK |
MBS147328-0002mg |
MyBiosource |
0.002mg |
EUR 240 |
Recombinant Human Betacellulin, HEK |
MBS147328-001mg |
MyBiosource |
0.01mg |
EUR 310 |
Recombinant Human Betacellulin, HEK |
MBS147328-1mg |
MyBiosource |
1mg |
EUR 5345 |
Recombinant Human Betacellulin, HEK |
MBS147328-5x1mg |
MyBiosource |
5x1mg |
EUR 23725 |
Human BTC -Betacellulin- CLIA Kit |
E-CL-H0444-24Tests |
Elabscience Biotech |
24 Tests |
EUR 180 |
|
Description: Sandwich |
Human BTC -Betacellulin- CLIA Kit |
E-CL-H0444-48Tests |
Elabscience Biotech |
48 Tests |
EUR 546 |
|
Description: Sandwich |
Human BTC -Betacellulin- CLIA Kit |
E-CL-H0444-96Tests |
Elabscience Biotech |
96 Tests |
EUR 682 |
|
Description: Sandwich |
Human BTC -Betacellulin- CLIA Kit |
E-CL-H0444-96Tests10 |
Elabscience Biotech |
96 Tests *10 |
EUR 6820 |
|
Description: Sandwich |
Human BTC -Betacellulin- CLIA Kit |
E-CL-H0444-96Tests5 |
Elabscience Biotech |
96 Tests *5 |
EUR 3410 |
|
Description: Sandwich |
Human bTC (Betacellulin) CLIA Kit |
MBS2531178-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2565 |
Human bTC (Betacellulin) CLIA Kit |
MBS2531178-96Tests |
MyBiosource |
96Tests |
EUR 560 |
Human Betacellulin Protein, Fc Tag |
BEN-H525x |
ACROBIOSYSTEMS |
1mg |
EUR 381.5 |
|
Description: Human Betacellulin, Fc Tag (BEN-H525x) is expressed from human 293 cells (HEK293). It contains AA Asp 32 - Tyr 111 (Accession # AAH11618). |
Anti-BTC/Betacellulin Antibody |
MBS2400715-005mg |
MyBiosource |
0.05mg |
EUR 595 |
Anti-BTC/Betacellulin Antibody |
MBS2400715-5x005mg |
MyBiosource |
5x0.05mg |
EUR 2500 |
Human BTC(Betacellulin) ELISA Kit |
EH0044 |
FN Test |
96T |
EUR 628.92 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml |
Human bTC (Betacellulin) ELISA Kit |
MBS2505147-10x96Tests |
MyBiosource |
10x96Tests |
EUR 4060 |
Human bTC (Betacellulin) ELISA Kit |
MBS2505147-24Tests |
MyBiosource |
24Tests |
EUR 265 |
Human bTC (Betacellulin) ELISA Kit |
MBS2505147-48Tests |
MyBiosource |
48Tests |
EUR 450 |
Human bTC (Betacellulin) ELISA Kit |
MBS2505147-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2265 |
Human bTC (Betacellulin) ELISA Kit |
MBS2505147-96Tests |
MyBiosource |
96Tests |
EUR 535 |
Human bTC (Betacellulin) ELISA Kit |
MBS8800404-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 3130 |
Human bTC (Betacellulin) ELISA Kit |
MBS8800404-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 350 |
Human bTC (Betacellulin) ELISA Kit |
MBS8800404-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 1710 |
Human bTC (Betacellulin) ELISA Kit |
MBS8800404-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 445 |
Human BTC(Betacellulin) ELISA Kit |
RE2928H-48wells |
Reed Biotech |
48 wells |
EUR 116.55 |
|
Human BTC(Betacellulin) ELISA Kit |
RE2928H-48wellsplate |
Reed Biotech |
48 wells plate |
EUR 126 |
Human BTC(Betacellulin) ELISA Kit |
RE2928H-96wells |
Reed Biotech |
96 wells |
EUR 161.55 |
|
Human BTC(Betacellulin) ELISA Kit |
RE2928H-96wellsplate |
Reed Biotech |
96 wells plate |
EUR 180 |
Recombinant Human Betacellulin
(rHuBTC) |
JOT-PR1006 |
Jotbody |
5µg |
EUR 205 |
|
Description: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg. |
Recombinant Human Betacellulin
(rHuBTC) |
PR1006 |
Bioworld Biotech |
5µg |
EUR 158 |
|
Description: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg. |
TRAF3 related to T cell GITR in a way dependent upon GITR ligation. TRAF3 additionally inhibited a number of occasions of the GITR mediated early signaling cascade, in a way impartial of recruitment of phosphatases, a mechanism by which TRAF3 inhibits signaling via a number of different cytokine receptors. These outcomes add new info to our understanding of GITR signaling and performance in T cells, which is related to the potential use of GITR to boost immune therapies.