Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to focus on HIV reservoirs. Monoclonal antibodies (mAbs) concentrating on the simian immunodeficiency virus (SIV) envelope allowed us to analyze the efficiency of single-chain variable fragment (scFv)-based anti-SIV CAR T cells.
In vitro, CAR T cells expressing the scFv to each the variable loop 1 (V1) or V3 of the SIV envelope have been extremely potent at eliminating SIV-infected T cells. Nevertheless, in preclinical research, in vivo infusion of those CAR T cells in rhesus macaques (RMs) resulted in lack of growth and no detectable in vivo antiviral exercise. Injection of envelope-expressing antigen-presenting cells (APCs) 1 week post-CAR T cell infusion additionally did not stimulate CAR T cell growth in vivo.
To analyze this in vitro versus in vivo discrepancy, we examined host immune responses directed at CAR T cells. A humoral immune response towards the CAR scFv was detected post-infusion of the anti-SIV CAR T cells; anti-SIV IgG antibodies current in plasma of SIV-infected animals have been related to inhibited CAR T cell effector features. These information point out that lack of in vivo growth and efficacy of CAR T cells is likely to be as a consequence of antibodies blocking the interplay between the CAR scFv and its epitope.
DLpTCR: an ensemble deep studying framework for predicting immunogenic peptide acknowledged by T cell receptor
Correct prediction of immunogenic peptide acknowledged by T cell receptor (TCR) can vastly profit vaccine improvement and most cancers immunotherapy. Nevertheless, figuring out immunogenic peptides precisely continues to be an enormous problem. Many of the antigen peptides predicted in silico fail to elicit immune responses in vivo with out contemplating TCR as a key issue. This inevitably causes pricey and time-consuming experimental validation take a look at for predicted antigens.
Subsequently, it’s essential to develop novel computational strategies for exactly and successfully predicting immunogenic peptide acknowledged by TCR. Right here, we described DLpTCR, a multimodal ensemble deep studying framework for predicting the probability of interplay between single/paired chain(s) of TCR and peptide introduced by main histocompatibility advanced molecules.
To analyze the generality and robustness of the proposed mannequin, COVID-19 information and IEDB information have been constructed for impartial analysis. The DLpTCR mannequin exhibited excessive predictive energy with space underneath the curve as much as 0.91 on COVID-19 information whereas predicting the interplay between peptide and single TCR chain.
Moreover, the DLpTCR mannequin achieved the general accuracy of 81.03% on IEDB information whereas predicting the interplay between peptide and paired TCR chains. The outcomes exhibit that DLpTCR has the flexibility to be taught basic interplay guidelines and generalize to antigen peptide recognition by TCR.
Receptor repertoires of murine follicular T helper cells reveal a excessive clonal overlap in separate lymph nodes in autoimmunity
Follicular T helper cells (Tfh) are a specialised subset of CD4 effector T cells which might be essential for germinal middle (GC) reactions and for choosing B cells to bear affinity maturation. Regardless of this central function for humoral immunity, solely few information exist about their clonal distribution when a number of lymphoid organs are uncovered to the identical antigen (Ag) as it’s the case in autoimmunity.
Right here, we used an autoantibody-mediated illness mannequin of the pores and skin and injected one auto-Ag into the 2 footpads of the identical mouse and analyzed the T cell receptor (TCR)β sequences of Tfh positioned in GCs of each contralateral draining lymph nodes. We discovered that over 90% of the dominant GC-Tfh clonotypes have been shared in each lymph nodes however solely transiently.
The initially dominant Tfh clonotypes particularly declined after institution of persistent illness whereas GC response and autoimmune illness continued. Our information demonstrates a dynamic habits of Tfh clonotypes underneath autoimmune situations and emphasizes the significance of the time level for distinguishing auto-Ag-specific Tfh clonotypes from potential bystander activated ones.
Dynamic adjustments within the T cell receptor repertoire throughout therapy with radiotherapy mixed with an immune checkpoint inhibitor
Earlier research have indicated a synergistic impact between radiotherapy and immunotherapy. A greater understanding of how this mixture impacts the immune system can assist to make clear its function within the therapy of metastatic most cancers. We carried out T cell receptor (TCR) sequencing on 46 sequentially collected samples from 15 sufferers with stage IV non-small cell lung most cancers, receiving stereotactic physique radiotherapy mixed with a programmed cell demise ligand-1 (PD-L1) inhibitor.
TCR repertoire variety was assessed utilizing Rényi variety curves and the Shannon variety index. TCR clones have been tracked over time. We discovered lowering or secure variety in one of the best responders, and a rise in variety at development in sufferers with an preliminary response. Enlargement of TCR clones was extra typically seen in responders.
A number of sufferers additionally developed new clones of excessive abundance. This appeared to be extra associated to radiotherapy than to immune checkpoint blockade. In abstract, we noticed comparable dynamics within the TCR repertoire as have been described with immunotherapy alone. As well as, the incidence of latest distinctive clones of excessive abundance after radiotherapy could point out that radiotherapy features as a personalised most cancers vaccine.
Tofacitinib Ameliorates Lupus Through Suppression of T Cell Activation Mediated by TGF-Beta Type I Receptor
Autoreactive T cells play an important function within the pathogenesis of systemic lupus erythematosus (SLE). TGF-β sort I receptor (TGFβRI) is pivotal in figuring out T cell activation. Right here, we confirmed that TGFβRI expression in naïve CD4+ T cells was decreased in SLE sufferers, particularly in these with excessive illness exercise.
Furthermore, IL-6 was discovered to downregulate TGFβRI expression by means of JAK/STAT3 pathway in SLE sufferers. In vitro, the JAK inhibitor tofacitinib inhibited SLE T cell activating by upregulating TGFβRI expression in a dose-dependent method. In MRL/lpr mice, tofacitinib therapy ameliorated the medical indicators and lupus nephritis, as evidenced by decreased plasma anti-dsDNA antibody ranges, decreased proteinuria, and decrease renal histopathological rating.
 Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein |
|
MBS2556751-005mg |
MyBiosource |
0.05mg |
EUR 305 |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein |
|
MBS2556751-5x005mg |
MyBiosource |
5x0.05mg |
EUR 1365 |
 Antibody) Anti-Mouse T-cell Immunoglobulin Mucin-2 (TIM-2) Antibody |
|
103-M275 |
ReliaTech |
100 µg |
EUR 399 |
|
Description: TIM-2 is a type I membrane protein and is a member of the TIM protein family. TIM-2 has an immunoglobulin variable region-like domain followed by a mucin-like domain in its extracellular region.This protein family is characterized by their conserved immunoglobulin and mucin domains, as well as by their expression on activated T cells. TIM-2 is a receptor for Semaphorin 4A, which is expressed on dendritic cells and B cells. Semaphorin 4A has been shown to enhance T cell activation. |
 Antibody) Anti-Mouse T-cell Immunoglobulin Mucin-3 (TIM-3) Antibody |
|
103-M276 |
ReliaTech |
100 µg |
EUR 399 |
|
Description: T cell immunoglobulin mucin-3 (TIM-3) is a member of the T-cell Immunoglobulin- and Mucin-domain-containing family of type I membrane glycoproteins that regulate autoimmune and allergic disease. TIM-3 is selectively expressed on Th1 cells and interacts with galectin-9. It negatively regulates Th1 responses and affects macrophage activation. The 280 aa mature human TIM-3 contains a V-type Ig-like domain that shows multiple polymorphisms, followed by a mucin-like domain in the 171 aa extracellular region, which shares 60% amino acid identity with mouse TIM-3 ECD. One splice variant of TIM-3 is truncated within the mucin domain and presumably is secreted. |
 Antibody) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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abx411874-01mg |
Abbexa |
0.1 mg |
EUR 644.4 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx415204-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx415206-01mg |
Abbexa |
0.1 mg |
EUR 526.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx433377-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx415206-200l |
Abbexa |
200 µl |
EUR 337.5 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx411874-100g |
Abbexa |
100 µg |
EUR 437.5 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx433377-100g |
Abbexa |
100 µg |
EUR 387.5 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx375362-96tests |
Abbexa |
96 tests |
EUR 337.5 |
) Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
AP76216 |
SAB |
1mg |
EUR 2649 |
|
|
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-10ug |
Novoprotein |
10ug |
EUR 151.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-1mg |
Novoprotein |
1mg |
EUR 2252.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-500ug |
Novoprotein |
500ug |
EUR 1593.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-50ug |
Novoprotein |
50ug |
EUR 278.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
 Antibody (PE)) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (PE) |
|
abx415207-200l |
Abbexa |
200 µl |
EUR 487.5 |
 Antibody (RPE)) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE) |
|
abx415207-100tests |
Abbexa |
100 tests |
EUR 710.4 |
|
|
) Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
AP76176 |
SAB |
1mg |
EUR 2369 |
|
|
) Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
AP76258 |
SAB |
1mg |
EUR 2649 |
|
|
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-10ug |
Novoprotein |
10ug |
EUR 151.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-1mg |
Novoprotein |
1mg |
EUR 2252.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-500ug |
Novoprotein |
500ug |
EUR 1593.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-50ug |
Novoprotein |
50ug |
EUR 278.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-10ug |
Novoprotein |
10ug |
EUR 132 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-1mg |
Novoprotein |
1mg |
EUR 2008.8 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-500ug |
Novoprotein |
500ug |
EUR 1423.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-50ug |
Novoprotein |
50ug |
EUR 278.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
 Antibody (FITC)) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC) |
|
abx415205-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC) |
|
abx415205-200l |
Abbexa |
200 µl |
EUR 400 |
 Antibody) T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody |
|
20-abx225210 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
|
|
|
T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody |
|
abx430303-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
|
 TIMD4 Antibody / T-cell immunoglobulin mucin receptor 4 |
|
RQ7456 |
NSJ Bioreagents |
100ug |
EUR 300.3 |
|
|
|
Description: T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene. |
 Timd2 Antibody / T-cell immunoglobulin mucin receptor 2 |
|
RQ7507 |
NSJ Bioreagents |
100ug |
EUR 300.3 |
|
|
|
Description: Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). |
 Antibody) T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx411875-01mg |
Abbexa |
0.1 mg |
EUR 661.2 |
|
|
 Antibody) T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
abx412054-01mg |
Abbexa |
0.1 mg |
EUR 844.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
abx415211-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
abx415213-01mg |
Abbexa |
0.1 mg |
EUR 526.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx415215-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx415216-01mg |
Abbexa |
0.1 mg |
EUR 526.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx415216-200l |
Abbexa |
200 µl |
EUR 337.5 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx411875-100tests |
Abbexa |
100 tests |
EUR 450 |
 Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 (AP)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP) |
|
MBS6248356-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP) |
|
MBS6248356-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (AP)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP) |
|
MBS6248358-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP) |
|
MBS6248358-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (PE)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE) |
|
MBS6252227-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE) |
|
MBS6252227-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (PE)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE) |
|
MBS6252229-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE) |
|
MBS6252229-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 Antibody (RPE)) T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE) |
|
abx415214-100tests |
Abbexa |
100 tests |
EUR 710.4 |
|
|
 (HRP)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP) |
|
MBS6251291-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP) |
|
MBS6251291-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (HRP)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP) |
|
MBS6251293-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP) |
|
MBS6251293-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (APC)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC) |
|
MBS6269208-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC) |
|
MBS6269208-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (APC)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC) |
|
MBS6269210-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC) |
|
MBS6269210-01mL |
MyBiosource |
0.1mL |
EUR 860 |
 Antibody (FITC)) T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC) |
|
abx415212-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
|
|
 (FITC)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC) |
|
MBS6250264-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC) |
|
MBS6250264-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (FITC)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC) |
|
MBS6250266-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC) |
|
MBS6250266-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 Antibody) Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
32146-05111 |
AssayPro |
150 ug |
EUR 215 |
 (Biotin)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin) |
|
MBS6249364-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin) |
|
MBS6249364-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (Biotin)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin) |
|
MBS6249366-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin) |
|
MBS6249366-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 Protein) Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein |
|
abx692171-100g |
Abbexa |
100 µg |
EUR 837.5 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein |
|
abx692171-1mg |
Abbexa |
1 mg |
Ask for price |
 (AP)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP) |
|
MBS6248357-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP) |
|
MBS6248357-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (PE)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE) |
|
MBS6252228-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE) |
|
MBS6252228-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (HRP)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP) |
|
MBS6251292-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP) |
|
MBS6251292-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (APC)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC) |
|
MBS6269209-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC) |
|
MBS6269209-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 ELISA Kit) Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
EKU11802-48T |
Biomatik Corporation |
48T |
EUR 571.55 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
EKU11802-5x96T |
Biomatik Corporation |
5x96T |
EUR 3878.38 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
EKU11802-96T |
Biomatik Corporation |
96T |
EUR 816.5 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
EKN52913-48T |
Biomatik Corporation |
48T |
EUR 355.6 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
EKN52913-5x96T |
Biomatik Corporation |
5x96T |
EUR 2413 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
EKN52913-96T |
Biomatik Corporation |
96T |
EUR 508 |
 - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2)) Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2) |
|
MG204271 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
abx549775-96tests |
Abbexa |
96 tests |
EUR 687.5 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2122181-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5455 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2122181-24StripWells |
MyBiosource |
24-Strip-Wells |
EUR 365 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2122181-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2122181-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2985 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2122181-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 740 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2707729-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 3215 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2707729-24StripWells |
MyBiosource |
24-Strip-Wells |
EUR 255 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2707729-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 340 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2707729-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 1675 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
|
MBS2707729-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 430 |
 (FITC)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (FITC) |
|
MBS6250265-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (FITC) |
|
MBS6250265-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 490)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490) |
|
MBS6254306-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490) |
|
MBS6254306-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 490)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 490) |
|
MBS6254308-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 490) |
|
MBS6254308-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 550)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550) |
|
MBS6255346-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550) |
|
MBS6255346-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 550)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 550) |
|
MBS6255348-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 550) |
|
MBS6255348-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 405)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405) |
|
MBS6253266-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405) |
|
MBS6253266-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 405)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 405) |
|
MBS6253268-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 405) |
|
MBS6253268-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 750)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750) |
|
MBS6257425-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750) |
|
MBS6257425-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 750)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 750) |
|
MBS6257427-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 750) |
|
MBS6257427-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 650)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650) |
|
MBS6256386-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650) |
|
MBS6256386-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 650)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 650) |
|
MBS6256388-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 650) |
|
MBS6256388-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4), (10ug)) Timd4 (untagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4), (10ug) |
|
MC214328 |
Origene Technologies GmbH |
10 µg |
Ask for price |
 ELISA Kit) Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (TIMD2) ELISA Kit |
|
abx549772-96tests |
Abbexa |
96 tests |
EUR 687.5 |
 Mouse Timd4 / T-cell immunoglobulin and mucin domain-containing protein 4 ELISA Kit |
|
E13605m |
EIAab |
96T |
EUR 776 |
 Mouse Timd4/T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 ELISA Kit |
|
MBS2890142-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 4080 |
Mouse Timd4/T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 ELISA Kit |
|
MBS2890142-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 390 |
Mouse Timd4/T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 ELISA Kit |
|
MBS2890142-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2220 |
Mouse Timd4/T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 ELISA Kit |
|
MBS2890142-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 520 |
 (Biotin)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (Biotin) |
|
MBS6249365-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (Biotin) |
|
MBS6249365-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
) Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
|
AP75076 |
SAB |
1mg |
EUR 3209 |
|
|
Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
|
C356-10ug |
Novoprotein |
10ug |
EUR 145.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
|
C356-1mg |
Novoprotein |
1mg |
EUR 2739.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
|
C356-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
|
C356-50ug |
Novoprotein |
50ug |
EUR 315.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
 ELISA Kit) Human T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) ELISA Kit |
|
SL3234Hu |
Sunlong |
96 Tests |
EUR 468 |
|
|
 - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4), (10ug)) Timd4 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4), (10ug) |
|
MG222206 |
Origene Technologies GmbH |
10 µg |
Ask for price |
 - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4)) Timd4 (Myc-DDK-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4) |
|
MR222206 |
Origene Technologies GmbH |
10 µg |
Ask for price |
) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS6506798-01mL |
MyBiosource |
0.1mL |
EUR 715 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS6506798-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3075 |
) Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS620755-01mg |
MyBiosource |
0.1mg |
EUR 810 |
Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS620755-5x01mg |
MyBiosource |
5x0.1mg |
EUR 3500 |
 (MaxLight 490)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 490) |
|
MBS6254307-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 490) |
|
MBS6254307-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 550)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 550) |
|
MBS6255347-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 550) |
|
MBS6255347-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 405)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 405) |
|
MBS6253267-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 405) |
|
MBS6253267-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 750)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 750) |
|
MBS6257426-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 750) |
|
MBS6257426-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 650)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 650) |
|
MBS6256387-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 650) |
|
MBS6256387-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
, partial) Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-005mgBaculovirus |
MyBiosource |
0.05mg(Baculovirus) |
EUR 1110 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-005mgMammalianCell |
MyBiosource |
0.05mg(Mammalian-Cell) |
EUR 1330 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-05mgEColi |
MyBiosource |
0.5mg(E-Coli) |
EUR 1110 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-05mgYeast |
MyBiosource |
0.5mg(Yeast) |
EUR 1330 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-1mgEColi |
MyBiosource |
1mg(E-Coli) |
EUR 1625 |
, partial) Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial |
|
MBS1377322-005mgBaculovirus |
MyBiosource |
0.05mg(Baculovirus) |
EUR 1140 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial |
|
MBS1377322-005mgMammalianCell |
MyBiosource |
0.05mg(Mammalian-Cell) |
EUR 1390 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial |
|
MBS1377322-05mgEColi |
MyBiosource |
0.5mg(E-Coli) |
EUR 1140 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial |
|
MBS1377322-05mgYeast |
MyBiosource |
0.5mg(Yeast) |
EUR 1390 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial |
|
MBS1377322-1mgEColi |
MyBiosource |
1mg(E-Coli) |
EUR 1745 |
 Mouse Hepatitis A virus cellular receptor 2/T-cell immunoglobulin and mucin-domain containing-3 ELISA kit |
|
E01A22718 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 (APC)) Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
|
MBS606914-100Tests |
MyBiosource |
100Tests |
EUR 935 |
Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
|
MBS606914-5x100Tests |
MyBiosource |
5x100Tests |
EUR 4050 |
 (AP)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP) |
|
MBS6241999-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP) |
|
MBS6241999-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
 (FITC)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC) |
|
MBS6243597-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC) |
|
MBS6243597-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
Constantly, tofacitinib enhanced TGFβRI expression and inhibited T cell activation in vivo. TGFβRI inhibitor SB431542 reversed the results of tofacitinib on T cell activation. Thus, our outcomes have indicated that tofacitinib can suppress T cell activation by upregulating TGFβRI expression, which gives a doable molecular mechanism underlying medical efficacy of tofacitinib in treating SLE sufferers.
