Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors

Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors post thumbnail image

For efficient focused remedy of most cancers with chemotherapy-loaded nanoparticles (NPs), antigens which might be selective for most cancers cells needs to be focused to minimise off-tumour toxicity. Human leukocyte antigens (HLAs) are engaging most cancers targets as they’ll current peptides from tumour-selective proteins on the cell floor, which will be recognised by T cells through T cell receptors (TCRs).

On this research, docetaxel-loaded polymeric NPs have been conjugated to recombinant affinity-enhanced TCRs to focus on breast most cancers cells presenting a tumour-selective peptide-HLA advanced. The TCR-conjugated nanoparticles enabled enhanced supply of docetaxel and induced cell demise via tumour-specific peptide-HLA concentrating on.

These in vitro knowledge reveal the potential of concentrating on tumour-restricted peptide-HLA epitopes utilizing excessive affinity TCR-conjugated nanoparticles, representing a novel remedy technique to ship therapeutic medication particularly to most cancers cells.

T cell receptor (TCR) is an integral a part of T cell recognition antigen, and the sum of TCR of all T cells in a person known as the TCR repertoire. Understanding the composition and traits of the TCR repertoire in wholesome and pathological state helps us to realize an perception into adaptive immunity.

At current, many evaluation instruments for high-throughput knowledge have been developed, together with primary composition evaluation and downstream operate evaluation. The database of antigen-specific T cells established by researchers is key to scientific analysis. The evaluation of the purposeful traits of the TCR repertoire is essential to the understanding of TCR repertoire.

Traits of Tcell receptor repertoire of stem cell-like reminiscence CD4+ T cells

Stem cell-like reminiscence T cells (Tscm) mix phenotypes of naïve and reminiscence. Nevertheless, it stays unclear how T cell receptor (TCR) traits contribute to heterogeneity in Tscm and different reminiscence T cells. We in contrast the TCR-beta (TRB) repertoire traits of CD4+ Tscm with these of naïve and different CD4+ reminiscence (Tm) in 16 human topics. In contrast with Tm, Tscm had an elevated variety throughout all stretches of TRB repertoire construction, a skewed gene utilization, and a shorter size distribution of CDR3 area.

These distinctions between Tscm and Tm have been enlarged in high1000 considerable clonotypes. Moreover, high1000 clonotypes in Tscm have been extra public than these in Tm and grouped in additional clusters, implying extra epitope sorts acknowledged by high1000 clonotypes in Tscm.

Importantly, self-reactive clonotypes have been public and enriched in Tscm quite than Tm, of sort one diabetes sufferers. Due to this fact, this research highlights the distinctive options of Tscm completely different from these of different reminiscence subsets and gives clues to know the physiological and pathological features of Tscm.

 Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors

Trapping or slowing the diffusion of T cell receptors at shut contacts initiates T cell signaling

T cell activation is initiated by T cell receptor (TCR) phosphorylation. This requires the native depletion of enormous receptor-type phosphatases from “shut contacts” shaped when T cells work together with surfaces presenting agonistic TCR ligands, however precisely how the ligands potentiate signaling is unclear. It has been proposed that TCR ligands might improve receptor phosphorylation and signaling simply by holding TCRs in phosphatase-depleted shut contacts, however this has not been instantly examined.

We devised easy strategies to maneuver the TCR out and in of shut contacts shaped by T cells interacting with supported lipid bilayers (SLBs) and to sluggish the receptor’s diffusion within the contacts, utilizing a collection of anti-CD3ε Fab- and ligand-based adducts of the receptor. TCRs participating a Fab prolonged with the massive extracellular area of CD45 have been excluded from contacts and produced no signaling.

Conversely, permitting the prolonged Fab to change into tethered to the SLB trapped the TCR within the shut contacts, resulting in very sturdy signaling. Importantly, attaching untethered anti-CD3ε Fab or peptide/MHC ligands, every of which have been largely inactive in answer however each of which diminished TCR diffusion in shut contacts roughly fivefold, additionally initiated signaling throughout cell/SLB contact.

Our findings point out that holding TCRs in shut contacts or just slowing their diffusion in phosphatase-depleted areas of the cell floor suffices to provoke signaling, results we might reproduce in single-particle stochastic simulations. Our research reveals that the TCR is preconfigured for signaling in a approach that enables it to be triggered by ligands performing merely as receptor “traps.”

Establishing a strong chimeric antigen receptor Tcell remedy program in Australia: the Royal Prince Alfred Hospital expertise

Chimeric antigen receptor (CAR) T-cell remedy is a novel permitted most cancers remedy that has proven outstanding efficacy within the remedy of sufferers with relapsed leukemia and lymphoma. Implementation of CAR T-cell remedy in a hospital setting requires cautious and detailed planning due to the complexities in delivering this specialist service. A multi-disciplinary strategy with devoted funding is required to satisfy scientific, scientific, logistic and regulatory necessities.

Tisagenlecleucel was the primary permitted CAR T-cell remedy in Australia. The remedy has been made accessible to Australian sufferers in specialist public hospitals via federal and state funding. Royal Prince Alfred Hospital (RPAH) is one in all Australia’s oldest tertiary referral public well being care establishments and was permitted for the supply of CAR T-cell remedy service in 2019.

A multi-disciplinary scientific program has been established for the gathering and cryopreservation of donor cells shipped for manufacturing in addition to for the receipt, storage and administration of CAR T-cell remedy and affected person administration. This system encompasses a Therapeutic Items Administration-accredited apheresis unit and a state-of-the-art facility for cell processing, cryopreservation and storage.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein

MBS2556751-005mg 0.05mg
EUR 305

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein

MBS2556751-5x005mg 5x0.05mg
EUR 1365

Anti-Mouse T-cell Immunoglobulin Mucin-1 (TIM-1) Antibody

103-M274 100 µg
EUR 399
Description: MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 74 aa cytoplasmic tail. The ECD consists of degenerate tandem repeats and a tandem repeat region, which makes up the major portion of the protein. Potential O-glycosylation sites (serines and threonines) make up more than one-fourth of the amino acids. Splicing variants produce ten isoforms for human MUC-1. Human MUC-1 is 28% aa identical to mouse MUC-1.

Anti-Mouse T-cell Immunoglobulin Mucin-3 (TIM-3) Antibody

103-M276 100 µg
EUR 399
Description: T cell immunoglobulin mucin-3 (TIM-3) is a member of the T-cell Immunoglobulin- and Mucin-domain-containing family of type I membrane glycoproteins that regulate autoimmune and allergic disease. TIM-3 is selectively expressed on Th1 cells and interacts with galectin-9. It negatively regulates Th1 responses and affects macrophage activation. The 280 aa mature human TIM-3 contains a V-type Ig-like domain that shows multiple polymorphisms, followed by a mucin-like domain in the 171 aa extracellular region, which shares 60% amino acid identity with mouse TIM-3 ECD. One splice variant of TIM-3 is truncated within the mucin domain and presumably is secreted.

Timd2 Antibody / T-cell immunoglobulin mucin receptor 2

RQ7507 100ug
EUR 300.3
Description: Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP)

MBS6248356-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP)

MBS6248356-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE)

MBS6252227-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE)

MBS6252227-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP)

MBS6251291-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP)

MBS6251291-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC)

MBS6269208-01mL 0.1mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC)

MBS6269208-5x01mL 5x0.1mL
EUR 3720

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

AP76216 1mg
EUR 2649

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC)

MBS6250264-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC)

MBS6250264-5x01mL 5x0.1mL
EUR 3720

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76176 1mg
EUR 2369

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76258 1mg
EUR 2649

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-10ug 10ug
EUR 132
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin)

MBS6249364-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin)

MBS6249364-5x01mL 5x0.1mL
EUR 3720

T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody

20-abx225210
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  • 100 ul
  • 200 ul
  • 50 ul

T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody

abx430303-200ul 200 ul
EUR 460.8

TIMD4 Antibody / T-cell immunoglobulin mucin receptor 4

RQ7456 100ug
EUR 300.3
Description: T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene.

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490)

MBS6254306-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490)

MBS6254306-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550)

MBS6255346-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550)

MBS6255346-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405)

MBS6253266-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405)

MBS6253266-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750)

MBS6257425-01mL 0.1mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750)

MBS6257425-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650)

MBS6256386-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650)

MBS6256386-5x01mL 5x0.1mL
EUR 3720

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-01mg 0.1 mg
EUR 644.4

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-01mg 0.1 mg
EUR 661.2

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx412054-01mg 0.1 mg
EUR 844.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415204-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415206-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415211-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415213-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415215-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx433377-200ul 200 ul
EUR 460.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415206-200l 200 µl
EUR 337.5

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-200l 200 µl
EUR 337.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-100g 100 µg
EUR 437.5

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-100tests 100 tests
EUR 450

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx433377-100g 100 µg
EUR 387.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx375362-96tests 96 tests
EUR 337.5

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-48StripWells 48-Strip-Wells
EUR 550

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-96StripWells 96-Strip-Wells
EUR 765

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (PE)

abx415207-200l 200 µl
EUR 487.5

Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2)

MG204271 10 µg Ask for price

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP)

MBS6248358-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP)

MBS6248358-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE)

MBS6252229-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE)

MBS6252229-5x01mL 5x0.1mL
EUR 3720

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE)

abx415207-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE)

abx415214-100tests 100 tests
EUR 710.4

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP)

MBS6251293-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP)

MBS6251293-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC)

MBS6269210-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC)

MBS6269210-01mL 0.1mL
EUR 860

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC)

abx415212-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-200l 200 µl
EUR 400

Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (TIMD2) ELISA Kit

abx549772-96tests 96 tests
EUR 687.5

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC)

MBS6250266-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC)

MBS6250266-5x01mL 5x0.1mL
EUR 3720

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-48StripWells 48-Strip-Wells
EUR 550

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-96StripWells 96-Strip-Wells
EUR 765

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

32146-05111 150 ug
EUR 215

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin)

MBS6249366-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin)

MBS6249366-5x01mL 5x0.1mL
EUR 3720

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx692171-100g 100 µg
EUR 837.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx692171-1mg 1 mg Ask for price

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS6506798-01mL 0.1mL
EUR 715

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS6506798-5x01mL 5x0.1mL
EUR 3075

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS620755-01mg 0.1mg
EUR 810

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS620755-5x01mg 5x0.1mg
EUR 3500

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS606914-100Tests 100Tests
EUR 935

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS606914-5x100Tests 5x100Tests
EUR 4050

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP)

MBS6241999-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP)

MBS6241999-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC)

MBS6243597-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC)

MBS6243597-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP)

MBS6244130-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP)

MBS6244130-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE)

MBS6244663-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE)

MBS6244663-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin)

MBS6243064-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin)

MBS6243064-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS6242532-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS6242532-5x01mL 5x0.1mL
EUR 4375

Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial

MBS1369680-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1110

Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial

MBS1369680-005mgMammalianCell 0.05mg(Mammalian-Cell)
EUR 1330

Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial

MBS1369680-05mgEColi 0.5mg(E-Coli)
EUR 1110

Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial

MBS1369680-05mgYeast 0.5mg(Yeast)
EUR 1330

Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial

MBS1369680-1mgEColi 1mg(E-Coli)
EUR 1625

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP)

MBS6248357-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP)

MBS6248357-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE)

MBS6252228-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE)

MBS6252228-5x01mL 5x0.1mL
EUR 3720

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 405)

MBS6245196-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 405)

MBS6245196-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 490)

MBS6245729-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 490)

MBS6245729-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 750)

MBS6247328-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 750)

MBS6247328-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 550)

MBS6246262-01mL 0.1(mL
EUR 1005

This system’s scientific experience extends to hematology, oncology, intensive care, pharmacy, neurology and radiology providers with direct expertise in managing sufferers receiving CAR T-cell therapies. The introduction of CAR T-cell therapies at RPAH was a posh enterprise facilitated by the present infrastructure and scientific experience.

 

 

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