For efficient focused remedy of most cancers with chemotherapy-loaded nanoparticles (NPs), antigens which might be selective for most cancers cells needs to be focused to minimise off-tumour toxicity. Human leukocyte antigens (HLAs) are engaging most cancers targets as they’ll current peptides from tumour-selective proteins on the cell floor, which will be recognised by T cells through T cell receptors (TCRs).
On this research, docetaxel-loaded polymeric NPs have been conjugated to recombinant affinity-enhanced TCRs to focus on breast most cancers cells presenting a tumour-selective peptide-HLA advanced. The TCR-conjugated nanoparticles enabled enhanced supply of docetaxel and induced cell demise via tumour-specific peptide-HLA concentrating on.
These in vitro knowledge reveal the potential of concentrating on tumour-restricted peptide-HLA epitopes utilizing excessive affinity TCR-conjugated nanoparticles, representing a novel remedy technique to ship therapeutic medication particularly to most cancers cells.
T cell receptor (TCR) is an integral a part of T cell recognition antigen, and the sum of TCR of all T cells in a person known as the TCR repertoire. Understanding the composition and traits of the TCR repertoire in wholesome and pathological state helps us to realize an perception into adaptive immunity.
At current, many evaluation instruments for high-throughput knowledge have been developed, together with primary composition evaluation and downstream operate evaluation. The database of antigen-specific T cells established by researchers is key to scientific analysis. The evaluation of the purposeful traits of the TCR repertoire is essential to the understanding of TCR repertoire.
Traits of T–cell receptor repertoire of stem cell-like reminiscence CD4+ T cells
Stem cell-like reminiscence T cells (Tscm) mix phenotypes of naïve and reminiscence. Nevertheless, it stays unclear how T cell receptor (TCR) traits contribute to heterogeneity in Tscm and different reminiscence T cells. We in contrast the TCR-beta (TRB) repertoire traits of CD4+ Tscm with these of naïve and different CD4+ reminiscence (Tm) in 16 human topics. In contrast with Tm, Tscm had an elevated variety throughout all stretches of TRB repertoire construction, a skewed gene utilization, and a shorter size distribution of CDR3 area.
These distinctions between Tscm and Tm have been enlarged in high1000 considerable clonotypes. Moreover, high1000 clonotypes in Tscm have been extra public than these in Tm and grouped in additional clusters, implying extra epitope sorts acknowledged by high1000 clonotypes in Tscm.
Importantly, self-reactive clonotypes have been public and enriched in Tscm quite than Tm, of sort one diabetes sufferers. Due to this fact, this research highlights the distinctive options of Tscm completely different from these of different reminiscence subsets and gives clues to know the physiological and pathological features of Tscm.
Trapping or slowing the diffusion of T cell receptors at shut contacts initiates T cell signaling
T cell activation is initiated by T cell receptor (TCR) phosphorylation. This requires the native depletion of enormous receptor-type phosphatases from “shut contacts” shaped when T cells work together with surfaces presenting agonistic TCR ligands, however precisely how the ligands potentiate signaling is unclear. It has been proposed that TCR ligands might improve receptor phosphorylation and signaling simply by holding TCRs in phosphatase-depleted shut contacts, however this has not been instantly examined.
We devised easy strategies to maneuver the TCR out and in of shut contacts shaped by T cells interacting with supported lipid bilayers (SLBs) and to sluggish the receptor’s diffusion within the contacts, utilizing a collection of anti-CD3ε Fab- and ligand-based adducts of the receptor. TCRs participating a Fab prolonged with the massive extracellular area of CD45 have been excluded from contacts and produced no signaling.
Conversely, permitting the prolonged Fab to change into tethered to the SLB trapped the TCR within the shut contacts, resulting in very sturdy signaling. Importantly, attaching untethered anti-CD3ε Fab or peptide/MHC ligands, every of which have been largely inactive in answer however each of which diminished TCR diffusion in shut contacts roughly fivefold, additionally initiated signaling throughout cell/SLB contact.
Our findings point out that holding TCRs in shut contacts or just slowing their diffusion in phosphatase-depleted areas of the cell floor suffices to provoke signaling, results we might reproduce in single-particle stochastic simulations. Our research reveals that the TCR is preconfigured for signaling in a approach that enables it to be triggered by ligands performing merely as receptor “traps.”
Establishing a strong chimeric antigen receptor T–cell remedy program in Australia: the Royal Prince Alfred Hospital expertise
Chimeric antigen receptor (CAR) T-cell remedy is a novel permitted most cancers remedy that has proven outstanding efficacy within the remedy of sufferers with relapsed leukemia and lymphoma. Implementation of CAR T-cell remedy in a hospital setting requires cautious and detailed planning due to the complexities in delivering this specialist service. A multi-disciplinary strategy with devoted funding is required to satisfy scientific, scientific, logistic and regulatory necessities.
Tisagenlecleucel was the primary permitted CAR T-cell remedy in Australia. The remedy has been made accessible to Australian sufferers in specialist public hospitals via federal and state funding. Royal Prince Alfred Hospital (RPAH) is one in all Australia’s oldest tertiary referral public well being care establishments and was permitted for the supply of CAR T-cell remedy service in 2019.
A multi-disciplinary scientific program has been established for the gathering and cryopreservation of donor cells shipped for manufacturing in addition to for the receipt, storage and administration of CAR T-cell remedy and affected person administration. This system encompasses a Therapeutic Items Administration-accredited apheresis unit and a state-of-the-art facility for cell processing, cryopreservation and storage.
 Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein |
|
MBS2556751-005mg |
MyBiosource |
0.05mg |
EUR 305 |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein |
|
MBS2556751-5x005mg |
MyBiosource |
5x0.05mg |
EUR 1365 |
 Antibody) Anti-Mouse T-cell Immunoglobulin Mucin-1 (TIM-1) Antibody |
|
103-M274 |
ReliaTech |
100 µg |
EUR 399 |
|
Description: MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 74 aa cytoplasmic tail. The ECD consists of degenerate tandem repeats and a tandem repeat region, which makes up the major portion of the protein. Potential O-glycosylation sites (serines and threonines) make up more than one-fourth of the amino acids. Splicing variants produce ten isoforms for human MUC-1. Human MUC-1 is 28% aa identical to mouse MUC-1. |
 Antibody) Anti-Mouse T-cell Immunoglobulin Mucin-3 (TIM-3) Antibody |
|
103-M276 |
ReliaTech |
100 µg |
EUR 399 |
|
Description: T cell immunoglobulin mucin-3 (TIM-3) is a member of the T-cell Immunoglobulin- and Mucin-domain-containing family of type I membrane glycoproteins that regulate autoimmune and allergic disease. TIM-3 is selectively expressed on Th1 cells and interacts with galectin-9. It negatively regulates Th1 responses and affects macrophage activation. The 280 aa mature human TIM-3 contains a V-type Ig-like domain that shows multiple polymorphisms, followed by a mucin-like domain in the 171 aa extracellular region, which shares 60% amino acid identity with mouse TIM-3 ECD. One splice variant of TIM-3 is truncated within the mucin domain and presumably is secreted. |
 Timd2 Antibody / T-cell immunoglobulin mucin receptor 2 |
|
RQ7507 |
NSJ Bioreagents |
100ug |
EUR 300.3 |
|
|
|
Description: Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). |
 (AP)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP) |
|
MBS6248356-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP) |
|
MBS6248356-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (PE)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE) |
|
MBS6252227-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE) |
|
MBS6252227-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (HRP)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP) |
|
MBS6251291-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP) |
|
MBS6251291-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (APC)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC) |
|
MBS6269208-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC) |
|
MBS6269208-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
) Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
AP76216 |
SAB |
1mg |
EUR 2649 |
|
|
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-10ug |
Novoprotein |
10ug |
EUR 151.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-1mg |
Novoprotein |
1mg |
EUR 2252.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-500ug |
Novoprotein |
500ug |
EUR 1593.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
|
CM03-50ug |
Novoprotein |
50ug |
EUR 278.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
 (FITC)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC) |
|
MBS6250264-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC) |
|
MBS6250264-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (Biotin)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin) |
|
MBS6249364-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin) |
|
MBS6249364-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
) Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
AP76176 |
SAB |
1mg |
EUR 2369 |
|
|
) Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
AP76258 |
SAB |
1mg |
EUR 2649 |
|
|
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-10ug |
Novoprotein |
10ug |
EUR 151.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-1mg |
Novoprotein |
1mg |
EUR 2252.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-500ug |
Novoprotein |
500ug |
EUR 1593.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CM54-50ug |
Novoprotein |
50ug |
EUR 278.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-10ug |
Novoprotein |
10ug |
EUR 132 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-1mg |
Novoprotein |
1mg |
EUR 2008.8 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-500ug |
Novoprotein |
500ug |
EUR 1423.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
|
CK57-50ug |
Novoprotein |
50ug |
EUR 278.4 |
|
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
 Antibody) T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody |
|
20-abx225210 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
|
|
|
T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody |
|
abx430303-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
|
 TIMD4 Antibody / T-cell immunoglobulin mucin receptor 4 |
|
RQ7456 |
NSJ Bioreagents |
100ug |
EUR 300.3 |
|
|
|
Description: T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene. |
 (MaxLight 490)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490) |
|
MBS6254306-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490) |
|
MBS6254306-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 550)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550) |
|
MBS6255346-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550) |
|
MBS6255346-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 405)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405) |
|
MBS6253266-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405) |
|
MBS6253266-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 750)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750) |
|
MBS6257425-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750) |
|
MBS6257425-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 650)) TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650) |
|
MBS6256386-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650) |
|
MBS6256386-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 Antibody) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx411874-01mg |
Abbexa |
0.1 mg |
EUR 644.4 |
|
|
 Antibody) T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx411875-01mg |
Abbexa |
0.1 mg |
EUR 661.2 |
|
|
 Antibody) T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
abx412054-01mg |
Abbexa |
0.1 mg |
EUR 844.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx415204-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx415206-01mg |
Abbexa |
0.1 mg |
EUR 526.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
abx415211-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
abx415213-01mg |
Abbexa |
0.1 mg |
EUR 526.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx415215-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx415216-01mg |
Abbexa |
0.1 mg |
EUR 526.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx433377-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx415206-200l |
Abbexa |
200 µl |
EUR 337.5 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx415216-200l |
Abbexa |
200 µl |
EUR 337.5 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx411874-100g |
Abbexa |
100 µg |
EUR 437.5 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
|
abx411875-100tests |
Abbexa |
100 tests |
EUR 450 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx433377-100g |
Abbexa |
100 µg |
EUR 387.5 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
|
abx375362-96tests |
Abbexa |
96 tests |
EUR 337.5 |
 Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
|
MBS3807468-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 Antibody (PE)) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (PE) |
|
abx415207-200l |
Abbexa |
200 µl |
EUR 487.5 |
 - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2)) Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2) |
|
MG204271 |
Origene Technologies GmbH |
10 µg |
Ask for price |
 (AP)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP) |
|
MBS6248358-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP) |
|
MBS6248358-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (PE)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE) |
|
MBS6252229-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE) |
|
MBS6252229-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 Antibody (RPE)) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE) |
|
abx415207-100tests |
Abbexa |
100 tests |
EUR 710.4 |
|
|
 Antibody (RPE)) T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE) |
|
abx415214-100tests |
Abbexa |
100 tests |
EUR 710.4 |
|
|
 (HRP)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP) |
|
MBS6251293-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP) |
|
MBS6251293-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (APC)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC) |
|
MBS6269210-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC) |
|
MBS6269210-01mL |
MyBiosource |
0.1mL |
EUR 860 |
 Antibody (FITC)) T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC) |
|
abx415205-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
|
|
 Antibody (FITC)) T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC) |
|
abx415212-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
|
|
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC) |
|
abx415205-200l |
Abbexa |
200 µl |
EUR 400 |
 ELISA Kit) Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (TIMD2) ELISA Kit |
|
abx549772-96tests |
Abbexa |
96 tests |
EUR 687.5 |
 (FITC)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC) |
|
MBS6250266-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC) |
|
MBS6250266-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 Antibody) Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
|
32146-05111 |
AssayPro |
150 ug |
EUR 215 |
 Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
|
MBS069521-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 (Biotin)) TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin) |
|
MBS6249366-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin) |
|
MBS6249366-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
antibody) T-cell immunoglobulin and mucin domain 1( TIM-1)antibody |
|
NBP0210-1 |
Bioworld Biotech |
each |
Ask for price |
|
|
|
Description: LF EIA,CLIA |
T-cell immunoglobulin and mucin domain 1( TIM-1)antibody |
|
NBP0210-2 |
Bioworld Biotech |
each |
Ask for price |
|
|
|
Description: LF EIA,CLIA |
 Protein) Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein |
|
abx692171-100g |
Abbexa |
100 µg |
EUR 837.5 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein |
|
abx692171-1mg |
Abbexa |
1 mg |
Ask for price |
) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS6506798-01mL |
MyBiosource |
0.1mL |
EUR 715 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS6506798-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3075 |
) Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS620755-01mg |
MyBiosource |
0.1mg |
EUR 810 |
Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
|
MBS620755-5x01mg |
MyBiosource |
5x0.1mg |
EUR 3500 |
 (APC)) Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
|
MBS606914-100Tests |
MyBiosource |
100Tests |
EUR 935 |
Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
|
MBS606914-5x100Tests |
MyBiosource |
5x100Tests |
EUR 4050 |
 (AP)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP) |
|
MBS6241999-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP) |
|
MBS6241999-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
 (FITC)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC) |
|
MBS6243597-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC) |
|
MBS6243597-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
 (HRP)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP) |
|
MBS6244130-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP) |
|
MBS6244130-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
 (PE)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE) |
|
MBS6244663-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE) |
|
MBS6244663-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
 (Biotin)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin) |
|
MBS6243064-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin) |
|
MBS6243064-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
 (APC)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
|
MBS6242532-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
|
MBS6242532-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4375 |
 (AP)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP) |
|
MBS6248357-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP) |
|
MBS6248357-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (PE)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE) |
|
MBS6252228-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE) |
|
MBS6252228-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
, partial) Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-005mgBaculovirus |
MyBiosource |
0.05mg(Baculovirus) |
EUR 1110 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-005mgMammalianCell |
MyBiosource |
0.05mg(Mammalian-Cell) |
EUR 1330 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-05mgEColi |
MyBiosource |
0.5mg(E-Coli) |
EUR 1110 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-05mgYeast |
MyBiosource |
0.5mg(Yeast) |
EUR 1330 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
|
MBS1369680-1mgEColi |
MyBiosource |
1mg(E-Coli) |
EUR 1625 |
 (HRP)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP) |
|
MBS6251292-01mL |
MyBiosource |
0.1(mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP) |
|
MBS6251292-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (APC)) TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC) |
|
MBS6269209-01mL |
MyBiosource |
0.1mL |
EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC) |
|
MBS6269209-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3720 |
 (MaxLight 405)) TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 405) |
|
MBS6245196-01mL |
MyBiosource |
0.1(mL |
EUR 1005 |
This system’s scientific experience extends to hematology, oncology, intensive care, pharmacy, neurology and radiology providers with direct expertise in managing sufferers receiving CAR T-cell therapies. The introduction of CAR T-cell therapies at RPAH was a posh enterprise facilitated by the present infrastructure and scientific experience.
