Chimeric antigen receptor-T cells immunotherapy for targeting breast cancer

Chimeric antigen receptor-T cells immunotherapy for targeting breast cancer post thumbnail image

Redirected chimeric antigen receptor (CAR) T-cells can acknowledge and eradicate most cancers cells in a serious histocompatibility advanced impartial method. Genetic engineering of T cells by means of CAR expression has yielded nice ends in the remedy of hematological malignancies in contrast with stable tumors.

There was a continuing effort to reinforce the effectiveness of those residing medication, attributable to their restricted success in focusing on stable tumors. Poor T cell trafficking, tumor-specific antigen choice, and the immunosuppressive tumor microenvironment are thought-about as the primary limitations in focusing on stable tumors by CAR T-cells.

Right here, we reviewed the present state of CAR T-cell remedy in breast most cancers, because the second cancer-related loss of life in ladies worldwide, in addition to some methods adopted to maintain the primary limitations of CAR T-cells beneath management. Additionally, we summarized varied approaches which have been developed to reinforce the therapeutic outcomes of this remedy in stable tumors focusing on.

The prognosis of sufferers with diffuse giant B-cell lymphoma a major refractory illness or relapsed inside 12 months after autologous hematopoietic cell transplantation is poor with a median survival of solely 6 months. With the brand new CD19-directed CAR T-cell remedy, 40% of the sufferers nonetheless obtain a long-term remission.

Nonetheless, this new remedy does convey new challenges resembling bridging the time through the CAR T-cell product time, and recognition of treatment-related unwanted effects resembling cytokine launch syndrome or neurotoxicity. Subsequently, remedy by a devoted, multidisciplinary group is critical. Future analysis will concentrate on extending CAR T-cell remedy to different illnesses and enhance remedy in non-responsiveness or resistance to CAR-T cell remedy.

Chimeric antigen receptor T cells self-neutralizing IL6 storm in sufferers with hematologic malignancy

IL6 is likely one of the most elevated cytokines throughout chimeric antigen receptor (CAR) T cell cytokine launch syndrome (CRS), and IL6R blockade by Tocilizumab has efficiently relieved essentially the most life-threatening elements of CRS in sufferers. As well as, newest research demonstrated the important function of IL1 in driving CART induced neurotoxicity in mouse fashions.

Right here we current a medical investigation of anti-CD19 and anti-BCMA CART (41BBζ) secreting an anti-IL6 scFv and IL1 receptor antagonist (IL1RA) in treating sufferers with hematologic malignancy. Our outcomes revealed that IL6 and IL1B had been maintained at low ranges with out important elevation throughout CRS, rendering Tocilizumab dispensable.

Furthermore, handled sufferers didn’t present neurotoxicity throughout CRS and exhibited delicate to average CRS. Notably, we noticed excessive price of full response (CR) and important CART growth throughout remedy. In sum, we conclude that CART-secreting anti-IL6 scFv and IL1RA may self-neutralize IL6 storm and keep low ranges of IL1B throughout CART remedy to reduce IL6- and IL1-associated cytokine toxicity and neurotoxicity with out impairing therapeutic efficacy.

 The power of a T cell to acknowledge international peptides is outlined by a single α and a single β hypervariable complementarity figuring out area (CDR3), which collectively kind the T cell receptor (TCR) heterodimer. In ∼30%-35% of T cells, two α chains are expressed on the mRNA stage however just one α chain is a part of the useful TCR. This impact can be noticed for β chains, though it’s much less widespread. The identification of useful α/β chain pairs is instrumental in high-throughput characterization of therapeutic TCRs.

TCRpair is the primary methodology that predicts whether or not an α and β chain pair types a useful, HLA-A*02:01 particular TCR with out requiring the sequence of a acknowledged peptide. By taking further amino acids flanking the CDR3 areas under consideration, TCRpair achieves an AUC of 0.71.

Characterization of the Therapeutic Results of Novel Chimeric Antigen Receptor T Cells Targeting CD38 on A number of Myeloma

A number of myeloma (MM) is a tumor kind characterised by the unregulated proliferation of clonal plasma cells within the bone marrow. Immunotherapy primarily based on chimeric antigen receptor T cell (CAR-T) remedy has achieved thrilling success within the remedy of hematological malignant tumors. CD38 is very and evenly expressed in MM and is a gorgeous goal for MM remedy.

Right here, we efficiently constructed two novel second-generation CAR-T cells focusing on CD38 by retroviral vector transduction. CD38 CAR-T cells might be activated successfully after stimulation with CD38-positive tumor cells and secrete cytokines resembling IFN-γ and TNF-α to advertise tumor cell apoptosis in in vitro experiments. Actual-time fluorescence monitoring experiments

luciferase detection experiments and stream cytometry experiments revealed the environment friendly and particular killing talents of CD38 CAR-T cells towards CD38-positive tumor cells. The proliferation skill of CD38 CAR-T cells in vitro was increased than that of untransduced T cells. Additional antitumor experiments in vivo confirmed that CD38 CAR-T cells might be shortly activated to secrete IFN-γ and get rid of tumors. Thus, novel CD38-targeted second-generation CAR-T cells have environment friendly and particular antitumor exercise and will grow to be a novel remedy for the medical remedy of MM.

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent method

The initiation and development of autoimmune problems resembling a number of sclerosis (MS) is linked to aberrant ldl cholesterol metabolism and overt irritation. Liver X receptors (LXR) are nuclear receptors that perform on the crossroads of ldl cholesterol metabolism and immunity, and their activation is taken into account a promising therapeutic technique to attenuate autoimmunity.

Nonetheless, regardless of clear useful heterogeneity and cell-specific expression profiles, the influence of the person LXR isoforms on autoimmunity stays poorly understood. Right here, we present that LXRα and LXRβ have an reverse influence on immune cell perform and illness severity within the experimental autoimmune encephalomyelitis mannequin, an experimental MS mannequin.

Whereas Lxrα deficiency aggravated illness pathology and severity, absence of Lxrβ was protecting. Guided by stream cytometry and through the use of cell-specific knockout fashions, lowered illness severity in Lxrβ-deficient mice was primarily attributed to modifications in peripheral T cell physiology and occurred impartial from alterations in microglia perform.

Recombinant mouse Prostate stem cell antigen

MBS9422457-05mg 0.5mg
EUR 1655

Recombinant mouse Prostate stem cell antigen

MBS9422457-5x05mg 5x0.5mg
EUR 7290

Mouse Prostate Stem Cell Antigen ELISA Kit

MBS057229-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Prostate Stem Cell Antigen ELISA Kit

MBS057229-48StripWells 48-Strip-Wells
EUR 550

Mouse Prostate Stem Cell Antigen ELISA Kit

MBS057229-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Prostate Stem Cell Antigen ELISA Kit

MBS057229-96StripWells 96-Strip-Wells
EUR 765

Mouse Prostate stem cell antigen ELISA Kit

MBS289860-10x96StripWells 10x96-Strip-Wells
EUR 4630

Mouse Prostate stem cell antigen ELISA Kit

MBS289860-48StripWells 48-Strip-Wells
EUR 440

Mouse Prostate stem cell antigen ELISA Kit

MBS289860-5x96StripWells 5x96-Strip-Wells
EUR 2480

Mouse Prostate stem cell antigen ELISA Kit

MBS289860-96StripWells 96-Strip-Wells
EUR 580

StemTAG Stem Cell Colony Formation Assay (Cell Recovery Compatible)

CBA-325 96 assays
EUR 1027.2
Description: Our StemTAG 96-Well Stem Cell Colony Formation Assay provides a high-throughput method to quantify ES cells in just 7-10 days, and no manual cell counting is required. Once colonies are formed, they may be analyzed in three different ways: 1. Lyse cells, then quantify in a fluorescence plate reader using dye included in the kit; 2. Lyse cells, then quantify alkaline phosphatase activity using reagents provided; or 3. Recover colonies from matrix for further culture or analysis.

StemTAG Stem Cell Colony Formation Assay (Cell Recovery Compatible)

CBA-325-5 5 x 96 assays
EUR 4033.2
Description: Our StemTAG 96-Well Stem Cell Colony Formation Assay provides a high-throughput method to quantify ES cells in just 7-10 days, and no manual cell counting is required. Once colonies are formed, they may be analyzed in three different ways: 1. Lyse cells, then quantify in a fluorescence plate reader using dye included in the kit; 2. Lyse cells, then quantify alkaline phosphatase activity using reagents provided; or 3. Recover colonies from matrix for further culture or analysis.

Recombinant Mouse Prostate stem cell antigen (Psca)

CSB-YP018840MO 5939 mg Ask for price

Recombinant Mouse Prostate stem cell antigen(Psca)

AP72740 each Ask for price

Recombinant Mouse Prostate stem cell antigen (Psca)

RPC20241-100ug 100ug
EUR 569.8

Recombinant Mouse Prostate stem cell antigen (Psca)

RPC20241-20ug 20ug
EUR 353.4

Recombinant Mouse Prostate stem cell antigen (Psca)

MBS962351-002mgYeast 0.02mg(Yeast)
EUR 320

Recombinant Mouse Prostate stem cell antigen (Psca)

MBS962351-01mgYeast 0.1mg(Yeast)
EUR 515

Recombinant Mouse Prostate stem cell antigen (Psca)

MBS962351-05mgYeast 0.5mg(Yeast)
EUR 1260

Recombinant Mouse Prostate stem cell antigen (Psca)

MBS962351-5x05mgYeast 5x0.5mg(Yeast)
EUR 5485

HESCA-1 (Human Embryonic Stem Cell Antigen-1)

MBS604449-01mg 0.1mg
EUR 785

HESCA-1 (Human Embryonic Stem Cell Antigen-1)

MBS604449-5x01mg 5x0.1mg
EUR 3385

Mouse Prostate stem cell antigen (PSCA) ELISA Kit

abx520719-96tests 96 tests
EUR 886.8

Mouse Psca/ Prostate stem cell antigen ELISA Kit

E1215Mo 1 Kit
EUR 543

Mouse Prostate stem cell antigen, Psca ELISA KIT

ELI-22375m 96tests
EUR 736

Mouse Prostate stem cell antigen (PSCA) ELISA Kit

RK13577 96T
EUR 280

Mouse Psca / Prostate stem cell antigen ELISA Kit

E8693m 96T
EUR 776

LY6E/Stem cell antigen 1 Polyclonal Antibody

MBS9236660-01mL 0.1mL
EUR 415

LY6E/Stem cell antigen 1 Polyclonal Antibody

MBS9236660-5x01mL 5x0.1mL
EUR 1841

StemTAG PCR Primer Set for Stem Cell Characterization

CBA-303 1 kit
EUR 470.4
Description: StemTAG PCR Primer Set for Stem Cell Characterization includes 7 primer pairs: Oct-4, NANOG, AFP, Flk-1, and NCAM, plus GAPDH and beta-actin as controls.

Total Protein - Murine Embryonic Stem Cell Line D3

CBA-305 500 ?g
EUR 414
Description:
  • Isolated from mouse ES-D3 cell line
  • Presented as 500 µg at 1 mg/mL in NP-40 Solubilization Buffer

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1)

MBS630318-01mg 0.1mg
EUR 665

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1)

MBS630318-5x01mg 5x0.1mg
EUR 2850

Prostate stem cell antigen

AP86675 1mg
EUR 2640

Prostate stem cell antigen

AP87071 1mg
EUR 2640

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (AP)

MBS6485594-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (AP)

MBS6485594-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) APC

MBS6485595-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) APC

MBS6485595-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (FITC)

MBS6485597-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (FITC)

MBS6485597-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (HRP)

MBS6485598-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (HRP)

MBS6485598-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (PE)

MBS6485604-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (PE)

MBS6485604-5x01mL 5x0.1mL
EUR 3990

OPCA01291-20UG - Recombinant Mouse Prostate stem cell antigen

OPCA01291-20UG 20ug
EUR 315

OPCA01291-100UG - Recombinant Mouse Prostate stem cell antigen

OPCA01291-100UG 100ug
EUR 462

OPCA01291-500UG - Recombinant Mouse Prostate stem cell antigen

OPCA01291-500UG 500ug
EUR 1276

Psca (untagged) - Mouse prostate stem cell antigen (Psca), (10ug)

MC211324 10 µg Ask for price

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (Biotin)

MBS6485596-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (Biotin)

MBS6485596-5x01mL 5x0.1mL
EUR 3990

CytoSelect Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit

CBA-254 96 assays
EUR 672
Description: Cell Biolabs? CytoSelect Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit is an enzyme immunoassay developed for the detection and quantitation of PCNA from nuclear and whole cell extracts.  The kit detects PCNA from mouse, rat and human, and has a detection sensitivity limit of 12.5 ng/mLPCNA.  Each kit provides sufficient reagents to perform up to 96 assays including standard curve and unknown samples. 

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 405)

MBS6485599-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 405)

MBS6485599-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 490)

MBS6485600-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 490)

MBS6485600-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 550)

MBS6485601-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 550)

MBS6485601-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 650)

MBS6485602-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 650)

MBS6485602-5x01mL 5x0.1mL
EUR 3990

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 750)

MBS6485603-01mL 0.1mL
EUR 920

LY6E (Lymphocyte Antigen 6E, Ly-6E, Retinoic Acid-induced Gene E Protein, RIG-E, Stem Cell Antigen 2, SCA-2, Thymic Shared Antigen 1, TSA-1, 9804, RIGE, SCA2, TSA1) (MaxLight 750)

MBS6485603-5x01mL 5x0.1mL
EUR 3990

Psca (GFP-tagged) - Mouse prostate stem cell antigen (Psca), (10ug)

MG215317 10 µg Ask for price

Psca (Myc-DDK-tagged) - Mouse prostate stem cell antigen (Psca)

MR215317 10 µg Ask for price

Prostate Stem Cell Antigen Antibody

8C0310 50ug
EUR 368
Description: Prostate Stem Cell Antigen Antibody

Prostate Stem Cell Antigen Antibody

33476 100ul
EUR 319

Prostate Stem Cell Antigen Antibody

33476-100ul 100ul
EUR 302.4

Prostate Stem Cell Antigen Antibody

33476-50ul 50ul
EUR 224.4

Prostate Stem Cell Antigen Antibody

E033476 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Prostate Stem Cell Antigen Antibody

E11-0310C 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Prostate Stem Cell Antigen Antibody

E19-8709-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Prostate Stem Cell Antigen Antibody

E19-8709-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Prostate Stem Cell Antigen Antibody

DF8709 200ul
EUR 420

Prostate Stem Cell Antigen Antibody

DF8709-100ul 100ul
EUR 280

Prostate Stem Cell Antigen Antibody

DF8709-200ul 200ul
EUR 350

Prostate Stem Cell Antigen Antibody

ABD8709 100ug
EUR 325

Prostate Stem Cell Antigen Antibody

MBS9400891-005mL 0.05mL
EUR 245

Prostate Stem Cell Antigen Antibody

MBS9400891-01mL 0.1mL
EUR 305

Prostate Stem Cell Antigen Antibody

MBS9400891-5x01mL 5x0.1mL
EUR 1230

Prostate Stem Cell Antigen Antibody

MBS8532743-005mg 0.05mg
EUR 235

Prostate Stem Cell Antigen Antibody

MBS8532743-01mg 0.1mg
EUR 305

Prostate Stem Cell Antigen Antibody

MBS8532743-01mLAF405M 0.1mL(AF405M)
EUR 465

Prostate Stem Cell Antigen Antibody

MBS8532743-01mLAF546 0.1mL(AF546)
EUR 465

Prostate Stem Cell Antigen Antibody

MBS8532743-01mLAF750 0.1mL(AF750)
EUR 465

Prostate Stem Cell Antigen Antibody

MBS853379-01mg 0.1mg
EUR 305

Prostate Stem Cell Antigen Antibody

MBS853379-01mLAF405L 0.1mL(AF405L)
EUR 465

Prostate Stem Cell Antigen Antibody

MBS853379-01mLAF405S 0.1mL(AF405S)
EUR 465

Prostate Stem Cell Antigen Antibody

MBS853379-01mLAF610 0.1mL(AF610)
EUR 465

Prostate Stem Cell Antigen Antibody

MBS853379-01mLAF635 0.1mL(AF635)
EUR 465

Prostate Stem Cell Antigen Antibody

MBS9609026-01mL 0.1mL
EUR 260

Prostate Stem Cell Antigen Antibody

MBS9609026-02mL 0.2mL
EUR 305

Prostate Stem Cell Antigen Antibody

MBS9609026-5x02mL 5x0.2mL
EUR 1220

Prostate Stem Cell Antigen Antibody

MBS9504710-005mL 0.05mL
EUR 285

Prostate Stem Cell Antigen Antibody

MBS9504710-01mL 0.1mL
EUR 385

Prostate Stem Cell Antigen Antibody

MBS9504710-5x01mL 5x0.1mL
EUR 1590

Prostate Stem Cell Antigen Antibody

MBS9510061-005mL 0.05mL
EUR 285

Prostate Stem Cell Antigen Antibody

MBS9510061-01mL 0.1mL
EUR 385

Prostate Stem Cell Antigen Antibody

MBS9510061-5x01mL 5x0.1mL
EUR 1590

Recombinant Mouse Prostate stem cell antigen Protein, His, Yeast-1mg

QP9353-ye-1mg 1mg
EUR 2763.6

Recombinant Mouse Prostate stem cell antigen Protein, His, Yeast-100ug

QP9353-ye-100ug 100ug
EUR 685.2

Recombinant Mouse Prostate stem cell antigen Protein, His, Yeast-10ug

QP9353-ye-10ug 10ug
EUR 326.4

Recombinant Mouse Prostate stem cell antigen Protein, His, Yeast-200ug

QP9353-ye-200ug 200ug
EUR 1077.6

Recombinant Mouse Prostate stem cell antigen Protein, His, Yeast-500ug

QP9353-ye-500ug 500ug
EUR 1806

Recombinant Mouse Prostate stem cell antigen Protein, His, Yeast-50ug

QP9353-ye-50ug 50ug
EUR 424.8

Ly-6A/E (Ly6A/E, Lymphocyte Antigen 6A-2/6E-1, Ly-6A.2/Ly-6E.1, Ly6a, Ly6, Ly-6A.2, Ly-6E.1, Stem Cell Antigen 1, Sca1, SCA-1, T-cell-activating Protein, TAP, Lymphocyte Activation Protein 6) (AP)

MBS6248099-01mL 0.1(mL
EUR 995

Ly-6A/E (Ly6A/E, Lymphocyte Antigen 6A-2/6E-1, Ly-6A.2/Ly-6E.1, Ly6a, Ly6, Ly-6A.2, Ly-6E.1, Stem Cell Antigen 1, Sca1, SCA-1, T-cell-activating Protein, TAP, Lymphocyte Activation Protein 6) (AP)

MBS6248099-5x01mL 5x0.1mL
EUR 4325

Prostate Stem Cell Antigen (PSCA) Antibody

20-abx102687
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Prostate Stem Cell Antigen (PSCA) Antibody

20-abx102688
  • Ask for price
  • Ask for price
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  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Prostate Stem Cell Antigen (PSCA) Antibody

20-abx132387
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prostate Stem Cell Antigen (PSCA) Antibody

20-abx114737
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Prostate Stem Cell Antigen (PSCA) Antibody

abx027872-400ul 400 ul
EUR 627.6

Prostate Stem Cell Antigen (PSCA) Antibody

abx027872-80l 80 µl
EUR 343.2

Prostate Stem Cell Antigen (PSCA) Antibody

20-abx013183
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  • Ask for price
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Prostate Stem Cell Antigen (PSCA) Antibody

20-abx008545
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  • 100 ul
  • 200 ul
  • 30 ul

Prostate Stem Cell Antigen (PSCA) Antibody

abx236848-100ug 100 ug
EUR 661.2

Prostate stem cell antigen (PSCA) Antibody

20-abx211961
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  • Ask for price
  • 100 ul
  • 50 ul

Prostate stem cell antigen (PSCA) Antibody

20-abx212351
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  • 100 ul
  • 50 ul

Prostate stem cell antigen (PSCA) Antibody

20-abx325516
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  • 100 ug
  • 50 ug

Prostate stem cell antigen (PSCA) Antibody

abx331721-100ul 100 ul
EUR 510

Prostate Stem Cell Antigen (PSCA) Antibody

abx433189-200ul 200 ul
EUR 343.2

Prostate Stem Cell Antigen (PSCA) Antibody

20-abx320478
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  • Ask for price
  • 100 ul
  • 50 ul

Prostate Stem Cell Antigen (PSCA), Antibody

GWB-983A18 1 ml Ask for price

Prostate Stem Cell Antigen (PSCA), Antibody

GWB-B3D35D 7 ml Ask for price

Prostate Stem Cell Antigen (PSCA) Antibody

abx114737-100l 100 µl
EUR 612.5

Prostate stem cell antigen (PSCA) Antibody

abx211961-100l 100 µl
EUR 350

Prostate stem cell antigen (PSCA) Antibody

abx211961-50l 50 µl
EUR 250

Prostate Stem Cell Antigen (PSCA) Antibody

abx027872-400l 400 µl
EUR 518.75

Prostate Stem Cell Antigen (PSCA) Antibody

abx236848-100g 100 µg
EUR 350

Prostate Stem Cell Antigen (PSCA) Antibody

abx132387-01mg 0.1 mg
EUR 275

Prostate stem cell antigen (PSCA) Antibody

abx212351-100l 100 µl
EUR 350

Prostate stem cell antigen (PSCA) Antibody

abx212351-50l 50 µl
EUR 250

Prostate stem cell antigen (PSCA) Antibody

abx325516-100g 100 µg
EUR 250

Prostate stem cell antigen (PSCA) Antibody

abx325516-50g 50 µg
EUR 187.5

Prostate Stem Cell Antigen (PSCA) Antibody

abx433189-100g 100 µg
EUR 387.5

Prostate Stem Cell Antigen (PSCA) Antibody

abx320478-100l 100 µl
EUR 350

Prostate Stem Cell Antigen (PSCA) Antibody

abx320478-50l 50 µl
EUR 237.5

Prostate Stem Cell Antigen (PSCA) Antibody

abx013183-100g 100 µg
EUR 237.5

Collectively, our findings point out that LXR isoforms play functionally non-redundant roles in autoimmunity, doubtlessly having broad implications for the event of LXR-based therapeutic methods aimed toward dampening autoimmunity and neuroinflammation.

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