Clonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein-Barr virus-associated nasopharyngeal carcinoma

Clonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein-Barr virus-associated nasopharyngeal carcinoma post thumbnail image

The nasopharyngeal epithelium is very prone to pathogenic an infection. Greater than 95% of nasopharyngeal carcinomas (NPCs) are Epstein-Barr virus (EBV)-associated epithelial cancers densely infiltrated with EBV-free lymphocytes. It stays unknown whether or not the immune modulating results of concurrent chemoradiotherapy (CCRT) on the tumor-infiltrating T-cell priming in opposition to EBV, tumor-associated antigens, and/or neoantigens can elicit systemic anti-tumor immunity and reduce recurrence or distant metastasis.

Utilizing matched EBV-associated NPCs, nasopharyngeal mucosal tissues, and longitudinal serial peripheral blood samples, we explored the spatiotemporal and quantitative modifications in enlargement and contraction of intratumoral T-cell clonotypes (ITCs) in peripheral blood samples from earlier than, throughout, and after CCRT.

The pre-treatment nasopharyngeal ITC repertoire contained distinctive mucosa-resident and generally system-shared T-cell receptors, portraying an individualized tumor-associated and/or metagenomic panorama. We discovered that the long-term disease-free sufferers had considerably extra sturdy distinctive mucosa-resident ITCs that migrated into and expanded within the peripheral blood after CCRT than within the sufferers with recurrence or distant metastasis.

Nonetheless, the system-shared productive ITC TCRs particular to the widespread viruses, akin to EBV, cytomegalovirus, and influenzaA, in all of the sufferers with and with out recurrence demonstrated virtually no enlargement after CCRT. Thus, these findings underline the significance of figuring out the impression of distinctive intratumoral immune responses, mirrored within the peripheral blood, on illness prognosis after therapy and problem of mechanistically understanding the widespread systemic immune evasion of EBV in NPC sufferers.

 Clonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein-Barr virus-associated nasopharyngeal carcinoma

We examine the structural and orientational variability of the membrane-embedded T cell receptor (TCR) – CD3 complicated in intensive atomistic molecular dynamics simulations based mostly on the current cryo-EM construction decided by Dong et al. (2019). We discover that the TCR extracellular (EC) area is very variable in its orientation by attaining tilt angles relative to the membrane regular that vary from 15° to 55°.

The lean angle of the TCR EC area is each coupled to a rotation of the area and to attribute modifications all through the TCR – CD3 complicated, particularly within the EC interactions of the C_ FG loop of the TCR, in addition to within the orientation of transmembrane helices. The concerted motions of the membrane-embedded TCR – CD3 complicated revealed in our simulations present atomistic insights on conformational modifications of the complicated in response to tilt-inducing forces on antigen-bound TCRs.

A mix of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident reminiscence γδ T cells

Though murine γδ T cells are largely thought of innate immune cells, they’ve lately been reported to type long-lived reminiscence populations. A lot stays unknown in regards to the biology and specificity of reminiscence γδ T cells. Right here, we interrogated intestinal reminiscence Vγ4 Vδ1 T cells generated after foodborne Listeria monocytogenes (Lm) an infection to uncover an unanticipated complexity within the specificity of those cells.

Deep TCR sequencing revealed {that a} subset of non-canonical Vδ1 clones are chosen by Lm an infection, per antigen-specific clonal enlargement. Ex vivo stimulations and in vivo heterologous problem infections with various pathogenic micro organism revealed that Lm-elicited reminiscence Vγ4 Vδ1 T cells are broadly reactive.

The Vγ4 Vδ1 T cell recall response to Lm, Salmonella enterica serovar Typhimurium (STm) and Citrobacter rodentium was largely mediated by the γδTCR as internalizing the γδTCR prevented T cell enlargement. Each broadly-reactive canonical and pathogen-selected non-canonical Vδ1 clones contributed to reminiscence responses to Lm and STm.

Curiously, some non-canonical γδ T cell clones chosen by Lm an infection additionally responded after STm an infection, suggesting some stage of cross-reactivity. These findings underscore the promiscuous nature of reminiscence γδ T cells and counsel that pathogen-elicited reminiscence γδ T cells are potential targets for broad-spectrum anti-infective vaccines.

Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITOk

The energy of peptide:MHC interactions with the T cell receptor (TCR) is correlated with the time to first cell division, the relative scale of the effector cell response, and the graded expression of activation-associated proteins like IRF4. To manage T cell activation programming, the TCR and the TCR proximal interleukin-2-inducible T cell kinase (ITK) concurrently set off many biochemically separate signaling cascades.

T cells missing ITK exhibit selective impairments in effector T cell responses after activation, however below the strongest signaling circumstances, ITK exercise is dispensable. To achieve perception into whether or not TCR sign energy and ITK exercise tune noticed graded gene expression by the unequal activation of distinct signaling pathways, we examined Erk1/2 phosphorylation or nuclear issue of activated T cells (NFAT) and nuclear issue (NF)-κB translocation in naïve OT-I CD8+ cell nuclei.

We noticed the constant digital activation of NFAT1 and Erk1/2, however NF-κB displayed dynamic, graded activation in response to variation in TCR sign energy, tunable by therapy with an ITK inhibitor. Inhibitor-treated cells confirmed the dampened induction of AP-1 elements Fos and Fosb, NF-κB response gene transcripts, and survival issue Il2 transcripts. ATAC sequencing evaluation additionally revealed that genomic areas most delicate to ITK inhibition had been enriched for NF-κB and AP-1 motifs.

Particular inhibition of NF-κB throughout peptide stimulation tuned the expression of early gene merchandise like c-Fos. Collectively, these knowledge point out a key function for ITK in orchestrating the optimum activation of separate TCR downstream pathways, particularly aiding NF-κB activation. Extra broadly, we revealed a mechanism by which variations in TCR sign energy can produce patterns of graded gene expression in activated T cells.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein

MBS2556751-001mg 0.01mg
EUR 170

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein

MBS2556751-005mg 0.05mg
EUR 305

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3 Protein

MBS2556751-5x005mg 5x0.05mg
EUR 1365

Anti-Mouse T-cell Immunoglobulin Mucin-3 (TIM-3) Antibody

103-M276 100 µg
EUR 399
Description: T cell immunoglobulin mucin-3 (TIM-3) is a member of the T-cell Immunoglobulin- and Mucin-domain-containing family of type I membrane glycoproteins that regulate autoimmune and allergic disease. TIM-3 is selectively expressed on Th1 cells and interacts with galectin-9. It negatively regulates Th1 responses and affects macrophage activation. The 280 aa mature human TIM-3 contains a V-type Ig-like domain that shows multiple polymorphisms, followed by a mucin-like domain in the 171 aa extracellular region, which shares 60% amino acid identity with mouse TIM-3 ECD. One splice variant of TIM-3 is truncated within the mucin domain and presumably is secreted.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

AP76216 1mg
EUR 2649

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76176 1mg
EUR 2369

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76258 1mg
EUR 2649

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-10ug 10ug
EUR 132
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Anti-Mouse T-cell Immunoglobulin Mucin-1 (TIM-1) Antibody

103-M274 100 µg
EUR 399
Description: MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 74 aa cytoplasmic tail. The ECD consists of degenerate tandem repeats and a tandem repeat region, which makes up the major portion of the protein. Potential O-glycosylation sites (serines and threonines) make up more than one-fourth of the amino acids. Splicing variants produce ten isoforms for human MUC-1. Human MUC-1 is 28% aa identical to mouse MUC-1.

Anti-Mouse T-cell Immunoglobulin Mucin-2 (TIM-2) Antibody

103-M275 100 µg
EUR 399
Description: TIM-2 is a type I membrane protein and is a member of the TIM protein family. TIM-2 has an immunoglobulin variable region-like domain followed by a mucin-like domain in its extracellular region.This protein family is characterized by their conserved immunoglobulin and mucin domains, as well as by their expression on activated T cells. TIM-2 is a receptor for Semaphorin 4A, which is expressed on dendritic cells and B cells. Semaphorin 4A has been shown to enhance T cell activation.

T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody

20-abx225210
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T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody

abx430303-200ul 200 ul
EUR 460.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx412054-01mg 0.1 mg
EUR 844.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415211-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415213-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE)

abx415214-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC)

abx415212-01mg 0.1 mg
EUR 610.8

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

32146-05111 150 ug
EUR 215

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-48StripWells 48-Strip-Wells
EUR 550

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit

MBS3807468-96StripWells 96-Strip-Wells
EUR 765

Timd2 Antibody / T-cell immunoglobulin mucin receptor 2

RQ7507 100ug
EUR 300.3
Description: Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).

TIMD4 Antibody / T-cell immunoglobulin mucin receptor 4

RQ7456 100ug
EUR 300.3
Description: T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene.

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP)

MBS6248357-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP)

MBS6248357-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE)

MBS6252228-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE)

MBS6252228-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP)

MBS6251292-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP)

MBS6251292-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC)

MBS6269209-01mL 0.1mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC)

MBS6269209-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (FITC)

MBS6250265-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (FITC)

MBS6250265-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (Biotin)

MBS6249365-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (Biotin)

MBS6249365-5x01mL 5x0.1mL
EUR 3720

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-01mg 0.1 mg
EUR 644.4

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-01mg 0.1 mg
EUR 661.2

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415204-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415206-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415215-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx433377-200ul 200 ul
EUR 460.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415206-200l 200 µl
EUR 337.5

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-200l 200 µl
EUR 337.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-100g 100 µg
EUR 437.5

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-100tests 100 tests
EUR 450

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx433377-100g 100 µg
EUR 387.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx375362-96tests 96 tests
EUR 337.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (PE)

abx415207-200l 200 µl
EUR 487.5

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP)

MBS6248356-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP)

MBS6248356-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP)

MBS6248358-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP)

MBS6248358-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE)

MBS6252227-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE)

MBS6252227-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE)

MBS6252229-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE)

MBS6252229-5x01mL 5x0.1mL
EUR 3720

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE)

abx415207-100tests 100 tests
EUR 710.4

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 490)

MBS6254307-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 490)

MBS6254307-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 550)

MBS6255347-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 550)

MBS6255347-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 405)

MBS6253267-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 405)

MBS6253267-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 750)

MBS6257426-01mL 0.1mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 750)

MBS6257426-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 650)

MBS6256387-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 650)

MBS6256387-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP)

MBS6251291-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP)

MBS6251291-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP)

MBS6251293-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP)

MBS6251293-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC)

MBS6269208-01mL 0.1mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC)

MBS6269208-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC)

MBS6269210-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC)

MBS6269210-01mL 0.1mL
EUR 860

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-200l 200 µl
EUR 400

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS6506798-01mL 0.1mL
EUR 715

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS6506798-5x01mL 5x0.1mL
EUR 3075

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS620755-01mg 0.1mg
EUR 810

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3)

MBS620755-5x01mg 5x0.1mg
EUR 3500

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-48StripWells 48-Strip-Wells
EUR 550

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit

MBS069521-96StripWells 96-Strip-Wells
EUR 765

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC)

MBS6250264-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC)

MBS6250264-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC)

MBS6250266-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC)

MBS6250266-5x01mL 5x0.1mL
EUR 3720

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

AP75076 1mg
EUR 3209

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS606914-100Tests 100Tests
EUR 935

Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS606914-5x100Tests 5x100Tests
EUR 4050

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP)

MBS6241999-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP)

MBS6241999-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC)

MBS6243597-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC)

MBS6243597-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP)

MBS6244130-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP)

MBS6244130-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE)

MBS6244663-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE)

MBS6244663-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin)

MBS6243064-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin)

MBS6243064-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS6242532-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC)

MBS6242532-5x01mL 5x0.1mL
EUR 4375

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (Biotin Conjugate)

32146-05121 150 ug
EUR 315

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin)

MBS6249364-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin)

MBS6249364-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin)

MBS6249366-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin)

MBS6249366-5x01mL 5x0.1mL
EUR 3720

Human T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) ELISA Kit

SL3234Hu 96 Tests
EUR 468

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 405)

MBS6245196-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 405)

MBS6245196-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 490)

MBS6245729-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 490)

MBS6245729-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 750)

MBS6247328-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 750)

MBS6247328-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 550)

MBS6246262-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 550)

MBS6246262-5x01mL 5x0.1mL
EUR 4375

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 650)

MBS6246795-01mL 0.1(mL
EUR 1005

TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (MaxLight 650)

MBS6246795-5x01mL 5x0.1mL
EUR 4375

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-1096T 10*96T
EUR 4122

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-48wells 48 wells
EUR 300

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-596T 5*96T
EUR 2061

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-96wells 96 wells
EUR 458

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-48StripWells 48-Strip-Wells
EUR 285

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-96StripWells 96-Strip-Wells
EUR 425

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx692171-100g 100 µg
EUR 837.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx692171-1mg 1 mg Ask for price

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

AP75656 1mg
EUR 3209

Mouse Hepatitis A virus cellular receptor 2/T-cell immunoglobulin and mucin-domain containing-3 ELISA kit

E01A22718 96T
EUR 700
Description: ELISA

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-48T 48T
EUR 571.55

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-5x96T 5x96T
EUR 3878.38

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-96T 96T
EUR 816.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-48T 48T
EUR 355.6

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-5x96T 5x96T
EUR 2413

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-96T 96T
EUR 508

Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2)

MG204271 10 µg Ask for price

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

abx549775-96tests 96 tests
EUR 687.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

MBS2122181-10x96StripWells 10x96-Strip-Wells
EUR 5455

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

MBS2122181-24StripWells 24-Strip-Wells
EUR 365

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

MBS2122181-48StripWells 48-Strip-Wells
EUR 550

The neurobiology of schizophrenia is multifactorial, comprising the dysregulation of a number of biochemical pathways and molecules. This analysis proposes a peripheral biomarker for schizophrenia that includes the second extracellular loop of norepinephrine transporter (NEText), the tropomyosin receptor kinase C (TrkC), and the neurotrophin-3 (NT-3) in T cells. The examine of NEText, NT-3, and TrkC was carried out in T cells and plasma extracted from peripheral blood of 54 sufferers with schizophrenia and 54 wholesome controls

 

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